2-Deoxy-D-glucose 6-phosphate sodium salt

SIAL/SMB00932 - ≥98% (HPLC)

Synonym: 2-Deoxy-D-glucose 6-phosphate sodium salt

CAS Number: 33068-19-8
Empirical Formula (Hill Notation): C₆H₁₃O₈P · xNa⁺
Molecular Weight: 244.14 (free acid basis)
MDL Number: MFCD00057477
Linear Formula: C₆H₁₃O₈P · xNa⁺
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-SMB00932-25MG	25 mg	$103.00 1/EA	Add To Favorites
45-SMB00932-50MG	50 mg	$137.00 1/EA	Add To Favorites
45-SMB00932-250MG	250 mg	$373.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white
form	powder
InChI	1S/C6H13O8P.Na.H/c7-2-1-4(8)6(10)5(9)3-14-15(11,12)13;;/h2,4-6,8-10H,1,3H2,(H2,11,12,13);;
InChI key	NBDKYLFTCAOTAK-UHFFFAOYSA-N
Quality Level	100
SMILES string	[Na].OC(COP(O)(O)=O)C(O)C(O)CC=O
solubility	water: 50 mg/mL, clear, colorless
storage temp.	−20°C

General description:

2-Deoxy-d-glucose (2DG) is a glucose molecule which has the 2-hydroxyl group replaced by hydrogen, so that it cannot undergo further glycolysis. As such, it acts to competitively inhibit the production of glucose-6-phosphate from glucose at the phosphoglucoisomerase level (step 2 of glycolysis). In most cells, glucose hexokinase phosphorylates 2-deoxyglucose, trapping the product 2-deoxyglucose-6-phosphate (2DG6P) intracellularly. 2DG & 2DG6P serve as good markers for tissue glucose uptake and hexokinase activity. For example, many cancers have elevated glucose uptake and hexokinase levels. 2DG6P undergoes only the first enzymatic reaction in the pentose phosphate pathway to generate 2-DG-6-phosphogluconolactone, which cannot be further metabolized.

WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	−20°C
UNSPSC	12352200

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