Dimethyl-L-arginine
SIAL/SMB00938 - ≥95% (HPLC)
Synonym: Dimethyl-L-arginine; (S)
CAS Number: 30315-93-6
Empirical Formula (Hill Notation): C8H18N4O2
Molecular Weight: 202.25
Linear Formula: C8H18N4O2
Product Type: Chemical
| assay | ≥95% (HPLC) |
| color | off-white |
| form | powder |
| Quality Level | 100  |
| Application: | Metabolomics |
| General description: | Asymmetric dimethylarginine (ADMA) is a naturally occurring chemical found in blood plasma. It is a metabolic by-product of continual protein modification processes in the cytoplasm of all human cells. It is closely related to L-arginine, a conditionally-essential amino acid. ADMA interferes with L-arginine in the production of nitric oxide, a key chemical to endothelial and hence cardiovascular health. Asymmetric dimethylarginine is created in protein methylation, a common mechanism of post-translational protein modification. This reaction is catalyzed by an enzyme set called S-adenosylmethionine protein N-methyltransferases (protein methylases I and II). The methyl groups transferred to create ADMA are derived from the methyl group donor S-adenosylmethionine, an intermediate in the metabolism of homocysteine. (Homocysteine is an important blood chemical, because it is also a marker of cardiovascular disease). After synthesis, ADMA migrates into the extracellular space and then into blood plasma. |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥95% (HPLC) |
| UNSPSC | 12352200 |