1-Methyladenosine
SIAL/SMB00939 - ≥95% (HPLC)
Synonym: 1-Methyladenosine; N1-Methyladenosine
CAS Number: 15763-06-1
Empirical Formula (Hill Notation): C11H15N5O4
Molecular Weight: 281.27
MDL Number: MFCD00038421
Linear Formula: C11H15N5O4
Product Type: Chemical
| assay | ≥95% (HPLC) |
| color | white |
| form | solid |
| Quality Level | 100  |
| SMILES string | CN1C=Nc2c(ncn2[C@@H]3O[C@ |
| storage temp. | -10 to -25°C |
| Application: | Metabolomics |
| General description: | 1-Methyladenosine, also known as M1A, belongs to the class of organic compounds known as purine nucleosides. Purine nucleosides are compounds comprising a purine base attached to a ribosyl or deoxyribosyl moiety. 1-Methyladenosine is a strong basic compound (based on its pKa). Precise m6A mapping by m6A-CLIP/IP (briefly m6A-CLIP) revealed that a majority of m6A locates in the last exon of mRNAs in multiple tissues/cultured cells of mouse and human, and the m6A enrichment around stop codons is a coincidence that many stop codons locate round the start of last exons where m6A is truly enriched. The methylation of adenosine is directed by a large m6A methyltransferase complex containing METTL3 as the SAM-binding sub-unit. Insulin-like growth factor-2 mRNA-binding proteins 1, 2, and 3 (IGF2BP1–3) are reported as a novel class of m6A readers. |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥95% (HPLC) |
| Storage Temp. | -10 to -25°C |
| UNSPSC | 12352200 |