N-Desethyl amodiaquine dihydrochloride
SIAL/SMB00947 - ≥95%
Synonym: Monodesethylamodiaquine dihydrochloride
CAS Number: 79049-30-2
Empirical Formula (Hill Notation): C18H18ClN3O · 2HCl
Molecular Weight: 400.73
Linear Formula: C18H18ClN3O · 2HCl
Product Type: Chemical
assay | ≥95% |
biological source | synthetic |
color | yellow to dark yellow |
form | solid |
Quality Level | 200 ![]() |
storage temp. | 2-8°C |
technique(s) | HPLC: suitable |
Application: | Amodiaquine (AQ) is currently used in combination with Artesunate (AS) as first-line treatment for some cases of falciparum malaria (UM) in many countries. AQ is metabolized by hepatic cytochrome P450 2C8 (CYP2C8) to Desethylamodiaquine (DAQ; DEAQ; NADQ; Ndes-amo), which is subsequently eliminated via extra-hepatic biotransformation by CYP1A1 and CYP1B1. DEAQ is responsible for the pharmacological activity of AQ (both therapeutic and toxicity) due to its long elimination half-life. |
Application: | Metabolomics research |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥95% |
Storage Temp. | 2-8°C |
UNSPSC | 12352200 |