O-Desmethyl gefitinib
SIAL/SMB00950 - ≥95%
Synonym: 4-
CAS Number: 847949-49-9
Empirical Formula (Hill Notation): C21H22ClFN4O3
Molecular Weight: 432.88
Linear Formula: C21H22ClFN4O3
Product Type: Chemical
assay | ≥95% |
biological source | synthetic |
color | light yellow to yellow |
form | solid |
grade | research grade |
Quality Level | 100 ![]() |
storage temp. | −20°C |
technique(s) | HPLC: suitable |
Application: | Metabolomics research |
General description: | O-Desmethyl gefitinib is a major active metabolite of gefitinib. It is a potent EGFR (erbB1/HER1) inhibitor (IC50 = 36 nM). Gefitinib is metabolized by CYP2D6 to O-Desmethyl gefitinib. Gefitinib is an EGFR inhibitor that is used to treat some types of cancers. |
Symbol | ![]() |
Signal word | Warning |
Hazard statements | H302 - H315 - H319 - H335 |
Precautionary statements | P261 - P264 - P270 - P301 + P312 - P302 + P352 - P305 + P351 + P338 |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥95% |
Storage Temp. | −20°C |
UNSPSC | 12352200 |