Etoposide quinone
SIAL/SMB00960
Synonym: Etoposide 3′,4′-quinone; Etoposide o-quinone
CAS Number: 105016-65-7
Empirical Formula (Hill Notation): C28H28O13
Molecular Weight: 572.51
Linear Formula: C28H28O13
Product Type: Chemical
| assay | ≥93% (H-NMR) |
| biological source | synthetic |
| color | dark red |
| form | solid |
| grade | research grade |
| Quality Level | 100  |
| storage temp. | −20°C |
| technique(s) | HPLC: suitable |
| Application: | Application: Metabolomics |
| General description: | Etoposide-quinone is a major metabolite of anticancer drug etoposide, which may contribute to the development of secondary acute myeloid leukemias in some etoposide patients. Etoposide-quinone is a covalent poison of human topoisomerase IIb, which induces four times more topoisomerase IIb mediated DNA cleavage than etoposide. Etoposide-quinone is a potent (IC50 = 7 μM) irreversible inhibitor of TCPTP protein tyrosine phosphatase that increases STAT1 tyrosine phosphorylation and contributes to etoposide dependent leukemogenesis. |
| Symbol |   GHS07,GHS08 |
| Signal word | Danger |
| Hazard statements | H302 - H350 - H361d |
| Precautionary statements | P201 - P202 - P264 - P270 - P301 + P312 - P308 + P313 |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥93% (H-NMR) |
| Storage Temp. | −20°C |
| UNSPSC | 12352200 |