Synonym: 7-Chloro-4-{[4-(ethylamino)-1-methylbutyl]amino}quinoline; 4-[[1-Methyl-4-((ethylamino)butyl]amino)]-7-chloroquinoline; 7-Chloro-4-(4-N-ethylamino-1-methylbutylamino)quinoline; N-Desethyl chloroquine; N-Desethylchloroquine; N4-(7-Chloro-4-quinolinyl)-N1-ethyl-1,4-pentanediamine; Monodeethylchloroquine; Monodesethylchloroqu​ine
CAS Number: 1476-52-4
Empirical Formula (Hill Notation): C16H22ClN3
Molecular Weight: 291.82
MDL Number: MFCD00871808
Linear Formula: C16H22ClN3
Product Type: Chemical
| assay |
≥95% (HPLC) |
| biological source |
synthetic |
| color |
white to off-white |
| form |
powder or crystals |
| grade |
research grade |
| InChI |
1S/C16H22ClN3/c1-3-18-9-4-5-12(2)20-15-8-10-19-16-11-13(17)6-7-14(15)16/h6-8,10-12,18H,3-5,9H2,1-2H3,(H,19,20) |
| InChI key |
MCYUUUTUAAGOOT-UHFFFAOYSA-N |
| Quality Level |
200  |
| shipped in |
wet ice |
| SMILES string |
ClC(C=C1)=CC2=C1C(NC(CCCNCC)C)=CC=N2 |
| storage temp. |
2-8°C |
| technique(s) |
HPLC: suitable |
| Application: |
Application: Metabolomics research |
| General description: |
Desethylchloroquine is a metabolite of hydroxychloroquine and chloroquine. Hydroxychloroquine and chloroquine have antimalarial properties and are used as a therapeutic for rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) and other inflammatory rheumatic diseases. They have also been in the spotlight due to their activity on patients with COVID-19, the disease caused by the SARS-CoV-2 virus. Hydroxychloroquine and chloroquine interfere with lysosomal activity and autophagy, interact with membrane stability and alter signalling pathways and transcriptional activity, which can result in modulation of cytokine production. Their mode of action is still emerging and their metabolism is of great interest. |
| Purity |
≥95% (HPLC) |
| Storage Temp. |
2-8°C |
| UNSPSC |
12352200 |
GHS07