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Bisdesethylchloroquine Hydrochloride

SIAL/SMB00975

Synonym: Bisdesethyl chloroquine hydrochloride; Didesethylchloroquine hydrochloride

Empirical Formula (Hill Notation): C14H18ClN3 · xHCl
Molecular Weight: 263.77 (free base basis)
MDL Number: MFCD00871854
Linear Formula: C14H18ClN3 · xHCl
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SMB00975-5MG 5 mg
 $185.00
1/EA		 Add To Favorites
45-SMB00975-25MG 25 mg
 $743.00
1/EA		 Add To Favorites

 

assay ≥95% (HPLC)
form solid
Quality Level 200 
storage temp. 2-8°C
Application: Metabolomics research
General description: Bisdesethylchloroquine is an immediate metabolite of hydroxychloroquine and chloroquine. These are antimalarial drugs used clinically in the treatment of rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) and other inflammatory rheumatic diseases. These drugs interfere with lysosomal activity and autophagy, interact with membrane stability and alter signalling pathways and transcriptional activity, which can result in modulation of cytokine production and certain co-stimulatory molecules. Hydroxychloroquine and chloroquine mode(s) of action are still emerging and their metabolism are of great interest. Metabolic Pathway: Cytochrome P450 drug.
Purity ≥95% (HPLC)
Storage Temp. 2-8°C

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