Reagent-cartridge VHL-PEG3
SIAL/SYNPLE-P023 - Synple
Synonym: Synple 2
Product Type: Chemical
Link the user selected aldehyde or ketone to the amine terminated linker through a reductive amination using the Synple 2 Automated Synthesizer.
Degrader building block reagent cartridge for use with Synple 2 Automated Synthesizer
| Quality Level | 100  |
| General description: | Reagent-cartridge VHL-PEG3 is a reagent cartridge for the Synple 2 Automated Synthesizer that enables the synthesis of molecules for targeted protein degradation and PROTAC® (proteolysis-targeting chimeras) research. The cartridge contains all necessary reagents for linking the user selected aldehyde or ketone to the amine terminated linker through a reductive amination. This cartridge features a von Hippel-Lindau (VHL) recruiting ligand ((S,R,S)-AHPC) and PEG linker. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and degrader, many analogs are prepared to screen for optimal target degradation. Scale: up to 0.1 mmol Linker: PEG3 E3 ligase target and ligand: von Hippel-Lindau (VHL), (S,R,S)-AHPC Terminal functional group: amine Compatible substrates: ketone, aldehyde Cartridge contents: • Reducing agent (supported cyanoborohydride) • Base (supported triethylamine) • SCX (for purification) • Degrader building block linker reagent Related Cartridges: • SYNPLE-P001 Reagent-cartridge CRBN-PEG1 • SYNPLE-P002 Reagent-cartridge CRBN-PEG2 • SYNPLE-P003 Reagent-cartridge CRBN-PEG3 • SYNPLE-P004 Reagent-cartridge CRBN-PEG4 • SYNPLE-P005 Reagent-cartridge CRBN-PEG5 • SYNPLE-P021 Reagent-cartridge VHL-PEG1 • SYNPLE-P022 Reagent-cartridge VHL-PEG2 • SYNPLE-P024 Reagent-cartridge VHL-PEG4 • SYNPLE-P025 Reagent-cartridge VHL-PEG5 Learn more about the Synple automated synthesis platform. Learn more about protein degradation.Explore all our Protein Degrader Building Blocks Features and Benefits of Synple Platform • Time savings - pre-installed protocols have been highly optimized, which obviates the need for the user′s own reaction development and optimization • Easy to use - protocols are loaded by simply scanning the cartridge; does not requires any programming knowledge • Safety - all chemicals are contained in the system, minimizing the user′s exposure • Set-up reaction in less than 5 minutes • Small footprint • Plug & Play system - simple installation • Reaction temperatures from 25 °C - 80 °C • Cartridges available for many different reactions • Prefilled with all required reagents • RFID chip containing optimized reaction protocol |
| Legal Information: | Product of Synple Chem AG |
| Legal Information: | PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license |
| Other Notes: | An integrated console for capsule-based, automated organic synthesis  |
| Symbol |  GHS07 |
| Signal word | Warning |
| Hazard statements | H315 - H319 |
| Precautionary statements | P264 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313 - P337 + P313 |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |