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4-Hydroxytamoxifen

SIAL/T176 - analytical standard, (E) and (Z) isomers (50:50)

Synonym: 4-(1-[4-(Dimethylaminoethoxy)phenyl]-2-phenyl-1-butenyl)phenol; 4-OHT; cis/trans-4-Hydroxytamoxifen

CAS Number: 68392-35-8
Empirical Formula (Hill Notation): C26H29NO2
Molecular Weight: 387.51
Linear Formula: C26H29NO2
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-T176-10MG 10 mg
 $90.60
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45-T176-50MG 50 mg
 $361.00
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antibiotic activity spectrum neoplastics
application(s) forensics and toxicology
pharmaceutical (small molecule)
form powder
format neat
grade analytical standard
InChI 1S/2C26H29NO2/c2*1-4-25(20-8-6-5-7-9-20)26(21-10-14-23(28)15-11-21)22-12-16-24(17-13-22)29-19-18-27(2)3/h2*5-17,28H,4,18-19H2,1-3H3/b26-25+;26-25-
InChI key ZJLDABGSDWXVGE-BDSXMVAQSA-N
mode of action enzyme | inhibits
Quality Level 200 
SMILES string CCC(c1ccccc1)=C(/c2ccc(O)cc2)c3ccc(OCCN(C)C)cc3.CCC(c4ccccc4)=C(c5ccc(O)cc5)c6ccc(OCCN(C)C)cc6
solubility ethanol: 20 mg/mL
technique(s) gas chromatography (GC): suitable
  HPLC: suitable
Application: The 4-Hydroxytamoxifen analytical standard can be used as follows:• Determination of tamoxifen and its three metabolites from dried blood spot (DBS) discs by ultra-high performance liquid chromatography-electrospray ionization-tandem mass spectrometry (UHPLC-ESI-MS/MS)
• Simultaneous estimation of tamoxifen, 4-hydroxytamoxifen, and endoxifen from DBS samples by UHPLC-MS/MS
• Development and validation of a non-aqueous capillary electrophoretic (NACE) method coupled with capacitively coupled contactless conductivity detection (C4D) to analyze tamoxifen and its three main metabolites after their liquid-liquid extraction (LLE) from human plasma samples obtained from breast cancer patients
• Multi-residue analysis of human plasma samples to quantify tamoxifen and its degradation products using the non-aqueous capillary electrophoretic (NACE) method combined with UV-detection
• Combined detection of tamoxifen and centchroman, along with their degradation products in human plasma samples by LC-ESI-MS/MS
Biochem/physiol Actions: Metabolite of the chemotherapeutic drug tamoxifen, exhibiting more potent estrogen agonist/antagonist activity than the parent drug. Also active as intra-membranous inhibitor of lipid peroxidation.
General description: 4-Hydroxytamoxifen is an antiestrogenic agent and one of the active metabolites of tamoxifen, formed upon its hydroxylation cytochrome P4502D6 (CYP2D6). Tamoxifen is used significantly in breast cancer as hormonal therapy.
Other Notes: Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Packaging: 10, 50 mg in poly bottle
UNSPSC 41116107

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