Tretinoin

SIAL/T1850000 - European Pharmacopoeia (EP) Reference Standard

Synonym: Retinoic acid; ATRA; Tretinoin; Vitamin A acid; all-trans-Retinoic acid

CAS Number: 302-79-4
Empirical Formula (Hill Notation): C₂₀H₂₈O₂
Molecular Weight: 300.44
MDL Number: MFCD00001551
Linear Formula: C₂₀H₂₈O₂
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-T1850000		$153.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

agency	EP
application(s)	pharmaceutical (small molecule)
biological source	synthetic
form	solid
format	neat
grade	pharmaceutical primary standard
InChI	1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14+
InChI key	SHGAZHPCJJPHSC-YCNIQYBTSA-N
manufacturer/tradename	EDQM
mp	180-181 °C (lit.)
SMILES string	CC1=C(C=CC(C)=CC=CC(C)=CC(O)=O)C(C)(C)CCC1
storage temp.	2-8°C
technique(s)	gas chromatography (GC): suitable
	liquid chromatography (LC): suitable

Application:	Tretinoin may be used as an analytical reference standard for the quantification of the analyte in dermatological formulations using high-performance liquid chromatography technique.
Biochem/physiol Actions:	all−trans−Retinoic acid (ATRA) is a ligand for both the retinoic acid receptor (RAR) and the retinoid X receptor (RXR). The bound RAR and RXR act as transcription factors that regulate the growth and differentiation of both normal and malignant cells. Cytochromes P450 (CYPs) catalyze the 4-hydroxylation of ATRA. Retinoic acid primes embryonic stem cells to become neurons.
Caution:	Please find SDS provided by EDQM here. .
General description:	This product is provided as delivered and specified by the issuing pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the authority of the issuing pharmacopoeia. For further information and support please go to the website of the issuing pharmacopoeia. Tretinoin is a medication used to treat a variety of skin conditions such as photodamaged skin, acne, etc. It is used as an anti-aging product and also as an oral treatment for leukemia.
Other Notes:	Sales restrictions may apply.
Packaging:	Unit quantity: 50 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue .

Symbol	GHS07
Signal word	Warning
Hazard statements	H302 - H315
Precautionary statements	P301 + P312 + P330 - P302 + P352
RIDADR	NONH for all modes of transport
WGK Germany	WGK 2
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

mp	180-181 °C (lit.)
Storage Temp.	2-8°C
UNSPSC	41116107

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