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Vincristine sulfate

SIAL/V8388 - meets USP testing specifications

Synonym: Vincristine sulfate salt; 22-Oxovincaleukoblastine sulfate salt; Leurocristine sulfate salt; VCR

CAS Number: 2068-78-2
Empirical Formula (Hill Notation): C46H56N4O10 · H2SO4
Molecular Weight: 923.04
EC Number: 218-190-0
MDL Number: MFCD00084729
Linear Formula: C46H56N4O10 · H2SO4
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-V8388-1MG 1 mg
 $0.00
1/EA
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45-V8388-5MG 5 mg
 $572.00
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This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material.

This image depicts SKU: V8388-25MG
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: V8388-1MG
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: V8388-5MG

 

agency meets USP testing specifications
  USP/NF
antibiotic activity spectrum neoplastics
application(s) pharmaceutical (small molecule)
InChI 1S/C46H56N4O10.H2O4S/c1-7-42(55)22-28-23-45(40(53)58-5,36-30(14-18-48(24-28)25-42)29-12-9-10-13-33(29)47-36)32-20-31-34(21-35(32)57-4)50(26-51)38-44(31)16-19-49-17-11-15-43(8-2,37(44)49)39(60-27(3)52)46(38,56)41(54)59-6;1-5(2,3)4/h9-13,15,20-21,26,28,37-39,47,55-56H,7-8,14,16-19,22-25H2,1-6H3;(H2,1,2,3,4)/t28-,37-,38+,39+,42-,43+,44+,45-,46-;/m0./s1
InChI key AQTQHPDCURKLKT-PNYVAJAMSA-N
mode of action protein synthesis | interferes
Quality Level 200 
SMILES string OS(O)(=O)=O.CC[C@]1(O)CC2CN(CCc3c([nH]c4ccccc34)[C@@](C2)(C(=O)OC)c5cc6c(cc5OC)N(C=O)C7[C@](O)([C@H](OC(C)=O)[C@]8(CC)C=CCN9CC[C@]67C89)C(=O)OC)C1
solubility ethanol: slightly soluble
  methanol: soluble
  water: freely soluble
storage temp. −20°C
Application: Vincristine sulfate has been used:
• as a positive control in potato disc anti-tumor bioassay
• as a standard cytotoxic agent
• to treat cells for manipulation of the microtubule network
Application: Widely used in cancer research. In studies on multi-drug resistance. Used to inhibit cell cycle progression at M-phase. Used to inhibit monoamine oxidase (MAO).
Biochem/physiol Actions: Vincristine sulfate possesses antitumor action targeting cell cycle. It prevents the action of tubulin by inhibiting microtubule polymerization. It also causes cell death and blocks metaphase in mitosis by preventing chromosome segregation. Vincristine sulfate inhibits angiogenesis mediated by factors such as vasculature endothelial growth factor. It decreases vascularization in tumors and normal tissues.
General description: Vincristine sulfate is an alkaloid present in Cantharanthus roseus.
Packaging: 1, 5 mg in glass bottle
Packaging: 25 mg in poly bottle
Storage Temp. −20°C
UNSPSC 12352210

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