Vincristine sulfate
SIAL/V8388 - meets USP testing specifications
Synonym: Vincristine sulfate salt; 22-
CAS Number: 2068-78-2
Empirical Formula (Hill Notation): C46H56N4O10 · H2SO4
Molecular Weight: 923.04
EC Number: 218-190-0
MDL Number: MFCD00084729
Linear Formula: C46H56N4O10 · H2SO4
Product Type: Chemical
agency | meets USP testing specifications |
USP/NF | |
antibiotic activity spectrum | neoplastics |
application(s) | pharmaceutical (small molecule) |
InChI | 1S/C46H56N4O10.H2O4S/c1-7 |
InChI key | AQTQHPDCURKLKT-PNYVAJAMSA |
mode of action | protein synthesis | interferes |
Quality Level | 200 ![]() |
SMILES string | OS(O)(=O)=O.CC[C@]1(O)CC2 |
storage temp. | −20°C |
Application: | Vincristine sulfate has been used: • as a positive control in potato disc anti-tumor bioassay • as a standard cytotoxic agent • to treat cells for manipulation of the microtubule network |
Application: | Widely used in cancer research. In studies on multi-drug resistance. Used to inhibit cell cycle progression at M-phase. Used to inhibit monoamine oxidase (MAO). |
Biochem/physiol Actions: | Vincristine sulfate possesses antitumor action targeting cell cycle. It prevents the action of tubulin by inhibiting microtubule polymerization. It also causes cell death and blocks metaphase in mitosis by preventing chromosome segregation. Vincristine sulfate inhibits angiogenesis mediated by factors such as vasculature endothelial growth factor. It decreases vascularization in tumors and normal tissues. |
General description: | Vincristine sulfate is an alkaloid present in Cantharanthus roseus. |
Packaging: | 1, 5 mg in glass bottle |
Packaging: | 25 mg in poly bottle |
Symbol | ![]() ![]() |
Signal word | Danger |
Hazard statements | H300 - H341 - H361fd |
Precautionary statements | P201 - P301 + P310 + P330 |
Hazard Codes | T |
Risk Statements | 63-25-62-68 |
Safety Statements | 36/37-45 |
RIDADR | UN 2811 6.1 / PGII |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Storage Temp. | −20°C |
UNSPSC | 12352200 |