Vincristine sulfate

SIAL/V8388 - meets USP testing specifications

Synonym: Vincristine sulfate salt; 22-Oxovincaleukoblastine sulfate salt; Leurocristine sulfate salt; VCR

CAS Number: 2068-78-2
Empirical Formula (Hill Notation): C₄₆H₅₆N₄O₁₀ · H₂SO₄
Molecular Weight: 923.04
EC Number: 218-190-0
MDL Number: MFCD00084729
Linear Formula: C₄₆H₅₆N₄O₁₀ · H₂SO₄
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-V8388-1MG	1 mg	$164.00 1/EA	Add To Favorites
45-V8388-5MG	5 mg	$556.00 1/EA	Add To Favorites
45-V8388-25MG	25 mg	$0.00 1/EA CALL FOR PRICE	Add To Favorites

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This image depicts SKU: V8388-25MG

Properties
Descriptions
Safety Info.
Basic Data

agency	meets USP testing specifications
	USP/NF
antibiotic activity spectrum	neoplastics
application(s)	pharmaceutical (small molecule)
InChI	1S/C46H56N4O10.H2O4S/c1-7-42(55)22-28-23-45(40(53)58-5,36-30(14-18-48(24-28)25-42)29-12-9-10-13-33(29)47-36)32-20-31-34(21-35(32)57-4)50(26-51)38-44(31)16-19-49-17-11-15-43(8-2,37(44)49)39(60-27(3)52)46(38,56)41(54)59-6;1-5(2,3)4/h9-13,15,20-21,26,28,37-39,47,55-56H,7-8,14,16-19,22-25H2,1-6H3;(H2,1,2,3,4)/t28-,37-,38+,39+,42-,43+,44+,45-,46-;/m0./s1
InChI key	AQTQHPDCURKLKT-PNYVAJAMSA-N
mode of action	protein synthesis \| interferes
Quality Level	200
SMILES string	OS(O)(=O)=O.CC[C@]1(O)CC2CN(CCc3c([nH]c4ccccc34)[C@@](C2)(C(=O)OC)c5cc6c(cc5OC)N(C=O)C7[C@](O)([C@H](OC(C)=O)[C@]8(CC)C=CCN9CC[C@]67C89)C(=O)OC)C1
storage temp.	−20°C

Application:	Vincristine sulfate has been used: • as a positive control in potato disc anti-tumor bioassay • as a standard cytotoxic agent • to treat cells for manipulation of the microtubule network
Application:	Widely used in cancer research. In studies on multi-drug resistance. Used to inhibit cell cycle progression at M-phase. Used to inhibit monoamine oxidase (MAO).
Biochem/physiol Actions:	Vincristine sulfate possesses antitumor action targeting cell cycle. It prevents the action of tubulin by inhibiting microtubule polymerization. It also causes cell death and blocks metaphase in mitosis by preventing chromosome segregation. Vincristine sulfate inhibits angiogenesis mediated by factors such as vasculature endothelial growth factor. It decreases vascularization in tumors and normal tissues.
General description:	Vincristine sulfate is an alkaloid present in Cantharanthus roseus.
Packaging:	1, 5 mg in glass bottle
Packaging:	25 mg in poly bottle

Symbol	GHS06,GHS08
Signal word	Danger
Hazard statements	H300 - H341 - H361fd
Precautionary statements	P201 - P301 + P310 + P330
Hazard Codes	T
Risk Statements	63-25-62-68
Safety Statements	36/37-45
RIDADR	UN 2811 6.1 / PGII
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Storage Temp.	−20°C
UNSPSC	12352200

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