Hydroxycarbamide
SIAL/Y0000119 - European Pharmacopoeia (EP) Reference Standard
Synonym: Hydroxyurea; Hydroxycarbamide
CAS Number: 127-07-1
Empirical Formula (Hill Notation): CH4N2O2
Molecular Weight: 76.05
MDL Number: MFCD00007943
Linear Formula: NH2CONHOH
Product Type: Chemical
| API family | hydroxycarbamide |
| application(s) | pharmaceutical (small molecule) |
| format | neat |
| grade | pharmaceutical primary standard |
| InChI | 1S/CH4N2O2/c2-1(4)3-5/h5H |
| InChI key | VSNHCAURESNICA-UHFFFAOYSA |
| manufacturer/tradename | EDQM |
| SMILES string | NC(=O)NO |
| storage temp. | 2-8°C |
| Application: | Hydroxycarbamide EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia. |
| Biochem/physiol Actions: | Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. |
| General description: | This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia   . |
| Other Notes: | Sales restrictions may apply. |
| Packaging: | The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue . |
| Symbol |  GHS08 |
| Signal word | Danger |
| Hazard statements | H340 - H361 |
| Precautionary statements | P201 - P308 + P313 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | 2-8°C |
| UNSPSC | 41116107 |