Letrozole
SIAL/Y0000685 - European Pharmacopoeia (EP) Reference Standard
Synonym: 4,4′-(1H-1,2,4-Triazol-1-ylmethylene)bisbenzonitrile
CAS Number: 112809-51-5
Empirical Formula (Hill Notation): C17H11N5
Molecular Weight: 285.30
MDL Number: MFCD00866241
Linear Formula: C17H11N5
Product Type: Chemical
| API family | letrozole |
| application(s) | pharmaceutical (small molecule) |
| format | neat |
| grade | pharmaceutical primary standard |
| InChI | 1S/C17H11N5/c18-9-13-1-5- |
| InChI key | HPJKCIUCZWXJDR-UHFFFAOYSA |
| manufacturer/tradename | EDQM |
| SMILES string | N#CC(C=C1)=CC=C1C(N2C=NC= |
| storage temp. | 2-8°C |
| Application: | Letrozole EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia. |
| Biochem/physiol Actions: | Letrozole is a third generation nonsteroidal aromatase inhibitor. It is a competitive inhibitor of the aromatase enzyme system and thus inhibits the conversion of androgens to estrogens. Letrozole inhibits the aromatase enzyme by competitively binding to the heme of the cytochrome P450 subunit of the enzyme, resulting in a reduction of estrogen biosynthesis in all tissues. |
| General description: | This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia   . |
| Other Notes: | Sales restrictions may apply. |
| Packaging: | The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue . |
| Symbol |  GHS08 |
| Signal word | Warning |
| Hazard statements | H361fd - H373 |
| Precautionary statements | P202 - P260 - P280 - P308 + P313 - P405 - P501 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | 2-8°C |
| UNSPSC | 41116107 |