Paclitaxel natural for peak identification
SIAL/Y0000700 - European Pharmacopoeia (EP) Reference Standard
Synonym: Paclitaxel
CAS Number: 33069-62-4
Empirical Formula (Hill Notation): C47H51NO14
Molecular Weight: 853.91
MDL Number: MFCD00869953
Linear Formula: C47H51NO14
Product Type: Chemical
application(s) | pharmaceutical (small molecule) |
format | neat |
grade | pharmaceutical primary standard |
InChI | 1S/C47H51NO14/c1-25-31(60 |
InChI key | RCINICONZNJXQF-MZXODVADSA |
manufacturer/tradename | EDQM |
mp | 213 °C (dec.) (lit.) |
SMILES string | [H][C@@]12C[C@H](O)[C@@]3 |
storage temp. | 2-8°C |
Biochem/physiol Actions: | Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase. The microtubule damage induces apoptosis through a JNK-dependent pathway followed by a JNK-independent pathway, perhaps related to the activation of protein kinase A (PKA) or of Raf-1 kinase, resulting in phosphorylation of Bcl-2. A major metabolite via CYP2CB is 6α-hydroxypaclitaxel (6α-OHP). |
Caution: | Paclitaxel undergoes transesterification in methanol and hydrolyzes in aqueous solutions. |
Caution: | Please find SDS provided by EDQM here. ![]() ![]() |
General description: | This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia ![]() ![]() |
Other Notes: | Sales restrictions may apply. |
Packaging: | Unit quantity: 10 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue ![]() ![]() |
Symbol | ![]() ![]() ![]() |
Signal word | Danger |
Hazard statements | H315 - H317 - H318 - H334 - H335 - H340 - H360D - H372 |
Precautionary statements | P202 - P260 - P280 - P302 + P352 - P305 + P351 + P338 - P308 + P313 |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
mp | 213 °C (dec.) (lit.) |
Storage Temp. | 2-8°C |
UNSPSC | 41116107 |