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Dexamethasone for system suitability

SIAL/Y0001177 - European Pharmacopoeia (EP) Reference Standard

Synonym: Dexamethasone; (11β,16α)-9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione; 9α-Fluoro-16α-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione; 9α-Fluoro-16α-methylprednisolone; Prednisolone F

CAS Number: 50-02-2
Empirical Formula (Hill Notation): C22H29FO5
Molecular Weight: 392.46
MDL Number: MFCD00064136
Linear Formula: C22H29FO5
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-Y0001177 15 mg
 $236.00
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agency EP
API family dexamethasone
application(s) pharmaceutical (small molecule)
biological source synthetic
form powder
format neat
grade pharmaceutical primary standard
InChI 1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,17+,19+,20+,21+,22+/m1/s1
InChI key UREBDLICKHMUKA-CXSFZGCWSA-N
manufacturer/tradename EDQM
mp 262-264 °C
  262-264 °C (lit.)
packaging pkg of 10 mg
shipped in ambient
SMILES string C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)CO
solubility water: <0.1 g/L
storage condition protect from light
storage temp. 2-8°C
Application: Dexamethasone is used as a pharmaceutical primary standard to quantify the analyte in pharmaceutical formulations using liquid chromatography (LC) technique.
Biochem/physiol Actions: Glucocorticoid anti-inflammatory agent
Biochem/physiol Actions: Glucocorticoid anti-inflammatory agent. Regulates T cell survival, growth, and differentiation. Inhibits the induction of nitric oxide synthase.
General description: Dexamethasone belongs to the class of synthetic glucocorticoid steroid drugs.
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia .
Other Notes: Sales restrictions may apply.
Packaging: The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue .
mp 262-264 °C (lit.); 262-264 °C
Storage Temp. 2-8°C
UNSPSC 41116107

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