Nicorandil
SIAL/Y0001761 - European Pharmacopoeia (EP) Reference Standard
Synonym: 2-
CAS Number: 65141-46-0
Empirical Formula (Hill Notation): C8H9N3O4
Molecular Weight: 211.17
MDL Number: MFCD00186520
Linear Formula: C8H9N3O4
Product Type: Chemical
| API family | nicorandil |
| application(s) | pharmaceutical (small molecule) |
| format | neat |
| grade | pharmaceutical primary standard |
| InChI | 1S/C8H9N3O4/c12-8(7-2-1-3 |
| InChI key | LBHIOVVIQHSOQN-UHFFFAOYSA |
| manufacturer/tradename | EDQM |
| SMILES string | [O-][N+](=O)OCCNC(=O)c1cc |
| storage temp. | −20°C |
| Application: | Nicorandil EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia. |
| Biochem/physiol Actions: | Nicorandil is a hybrid ATP-sensitive K+ (KATP) channel opener and nicotinamide nitrate NO donor. Nicorandil selectively activates SUR2B- versus SUR2A-containing KATP channels. It enhances endothelial NO synthase expression and protects against ischemic ventricular arrhythmias. By activating potassium channels, and donating nitric oxide to activate the enzyme guanylate cyclase, Nicorandil causes activation of GMP leading to both arterial and venous vasodilatation. Nicorandil is selective for vascular potassium channels, but has no significant action on cardiac contractility and conduction. |
| General description: | This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia   . |
| Other Notes: | Sales restrictions may apply. |
| Packaging: | The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue . |
| Symbol |   GHS02,GHS07 |
| Signal word | Danger |
| Hazard statements | H242 - H302 |
| Precautionary statements | P210 - P235 - P280 - P301 + P312 - P370 + P378 - P410 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352200 |