Tetrahydrofuran
SIGALD/178810 - ReagentPlus®, ≥99.0%, contains 250 ppm BHT as inhibitor
Synonym: THF; Butylene oxide; Oxolane; Tetramethylene oxide
CAS Number: 109-99-9
Empirical Formula (Hill Notation): C4H8O
Molecular Weight: 72.11
EC Number: 203-726-8
MDL Number: MFCD00005356
Linear Formula: C4H8O
Product Type: Chemical
assay | ≥99.0% |
autoignition temp. | 610 °F |
bp | 65-67 °C (lit.) |
contains | 250 ppm BHT as inhibitor |
density | 0.889 g/mL at 25 °C (lit.) |
expl. lim. | 1.8-11.8 % |
form | liquid |
InChI | 1S/C4H8O/c1-2-4-5-3-1/h1- |
InChI key | WYURNTSHIVDZCO-UHFFFAOYSA |
mp | −108 °C (lit.) |
pH | ~7 |
product line | ReagentPlus® |
Quality Level | 100 ![]() |
refractive index | n |
SMILES string | C1CCOC1 |
vapor density | 2.5 (vs air) |
vapor pressure | 114 mmHg ( 15 °C) |
143 mmHg ( 20 °C) |
Application: | Tetrahydrofuran may be used for the dissolution of poly-ε-caprolactone (PCL) and 1,3-diaminopentane, during the preparation of poly-ε-caprolactone (PCL)-hydroxyapatite (HA) scaffolds and acrylate-terminated poly(5-amino-1-pentanol-c |
General description: | Tetrahydrofuran (THF) is a saturated cyclic ether mainly used as an organic solvent. On long term storage it forms organic peroxides. This process can be suppressed by adding butylated hydroxytoluene (BHT) as a stabilizer. BHT removes the free radicals required for the peroxide formation. THF constitutes the key fragment of various natural products (polyether antibiotics). THF can form a double hydrate with hydrogen sulfide. Crystal structure of this double hydrate has been investigated by three-dimensional single-crystal studies. Butane-1,4-diol is formed as an intermediate during the synthesis of THF. Hot THF is useful for the dissolution of polyvinylidene chloride (PVDV). |
Legal Information: | ReagentPlus is a registered trademark of Merck KGaA, Darmstadt, Germany |
Other Notes: | For information on tetrahydrofuran miscibility, please visit the following link: Tetrahydrofuran Miscibility/Immiscibility Table ![]() ![]() Greener alternatives are available for many THF applications, 2-Methyltetrahydrofuran (155810 ![]() ![]() Read more about THF alternatives: 2-Methyltetrahydroun (2-MeTHF): A biomass-Derived solvent with Broad Applications in Organic Chemistry The toxicological assessment of cyclopentyl methyl ether (CPME) as a green solvent |
Packaging: | 1, 4 L in glass bottle |
Packaging: | 18 L in steel drum |
Symbol | ![]() ![]() ![]() |
Signal word | Danger |
Hazard statements | H225 - H302 - H319 - H335 - H336 - H351 |
Precautionary statements | P201 - P202 - P210 - P301 + P312 - P305 + P351 + P338 - P308 + P313 |
Hazard Codes | F,Xn |
Risk Statements | 11-19-36/37-40 |
Safety Statements | 13-16-29-33-36-37-46 |
RIDADR | UN 2056 3 / PGII |
WGK Germany | WGK 1 |
Flash Point(F) | -6.2 °F - closed cup |
Flash Point(C) | -21.2 °C - closed cup |
Supplemental Hazard Statements | EUH018 - EUH019 |
Purity | ≥99.0% |
bp | 65-67 °C (lit.) |
mp | −108 °C (lit.) |
Density | 0.889 g/mL at 25 °C (lit.) |
Refractive Index | n |
UNSPSC | 12191501 |