Osmium tetroxide
SIGALD/201030 - ReagentPlus®, 99.8%
Synonym: Osmium(VIII)-oxide; ‘Osmic acid’
CAS Number: 20816-12-0
Empirical Formula (Hill Notation): O4Os
Molecular Weight: 254.23
EC Number: 244-058-7
MDL Number: MFCD00011150
Linear Formula: OsO4
Product Type: Chemical
| assay | 99.8% |
| bp | 130 °C (lit.) |
| form | crystalline |
| powder | |
| InChI | 1S/4O.Os |
| InChI key | VUVGYHUDAICLFK-UHFFFAOYSA |
| mp | 39.5-41 °C (lit.) |
| product line | ReagentPlus® |
| Quality Level | 200  |
| reaction suitability | reagent type: oxidant |
| SMILES string | O=[Os](=O)(=O)=O |
| storage temp. | 2-8°C |
| vapor density | 8.8 (vs air) |
| vapor pressure | 7 mmHg ( 20 °C) |
| Application: | Osmium tetroxide may be employed as a catalyst for the hydroxylation of sterically hindered olefins. |
| Application: | Osmium tetroxide may be used in the following processes: • To promote the lactonization of alkenols to lactones. • To mediate the selective oxidative cleavage of olefins by oxone to form the corresponding ketones or carboxylic acids. • Dihydroxylation of mono-trans-di, and trisubstituted olefins to form 1,2-diols with high enantioselectivity in the presence of chiral amines. |
| Application: | Widely used oxidizer for visualizing cells in microscopy. Promotes oxidative cleavage of graphene layers in carbon nanotubes creating the possibility of opening ′windows′ in fullerene cages. |
| General description: | Osmium tetroxide (OsO4) is widely employed as a catalyst in various organic reactions. Stereochemical aspects of the OsO4 assisted oxidation of allylic alcohols and their derivatives have been reported. Its reaction with olefins has been investigated. It participates as a catalyst for oxidizing fluoroquinolones, via reaction with potassium hexacyanoferrate(III) in alkaline medium. Kinetics of this oxidation reaction was studied. |
| Legal Information: | ReagentPlus is a registered trademark of Sigma-Aldrich Co. LLC |
| Packaging: | 1 g in ampule |
| Packaging: | 250, 500 mg in ampule |
| Symbol |   GHS05,GHS06 |
| Signal word | Danger |
| Hazard statements | H300 + H310 + H330 - H314 |
| Precautionary statements | P260 - P270 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 |
| Hazard Codes | T+ |
| Risk Statements | 26/27/28-34 |
| Safety Statements | 7/9-26-45 |
| RIDADR | UN 2471 6.1 / PGI |
| WGK Germany | WGK 1 |
| Purity | 99.8% |
| bp | 130 °C (lit.) |
| mp | 39.5-41 °C (lit.) |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352300 |