Hydrogen chloride solution
SIGALD/345547 - 4.0 M in dioxane
CAS Number: 7647-01-0
Empirical Formula (Hill Notation): HCl
Molecular Weight: 36.46
MDL Number: MFCD00011324
Linear Formula: HCl
Product Type: Chemical
| concentration | 3.80-4.40 M (by NaOH, titration) |
| 4.0 M in dioxane | |
| density | 1.05 g/mL at 25 °C |
| form | liquid |
| InChI | 1S/ClH/h1H |
| InChI key | VEXZGXHMUGYJMC-UHFFFAOYSA |
| Quality Level | 200  |
| SMILES string | Cl |
| Application: | Hydrogen chloride solution (4.0 M in dioxane) can be used as: • A reagent for the deprotection of the N-Boc protecting group from various heterocyclic derivatives. • A reagent for the deprotection of polymer protecting groups. For instance, deprotection of benzyl ether-protected polymer. • A polymerization initiator in combination with ZnCl2 in the synthesis of formyl terminated poly(ethyl vinyl ether) from ethyl vinyl ether (EVE). |
| General description: | Hydrogen chloride solution contains 4.0 M hydrogen chloride in 1,4-dioxane as the solvent. It is commonly used as a deprotection reagent during the deprotection of the tert-butoxycarbonyl (Boc) group of various amino acids and peptides. Additionally, it serves as a reagent in various organic synthesis reactions, including the synthesis of N-9-Fluorenylmethoxycarbon |
| Packaging: | 100, 4×100, 800 mL in Sure/Seal™ |
| Packaging: | 2 L in Sure/Seal™ |
| Symbol |     GHS02,GHS05,GHS07,GHS08 |
| Signal word | Danger |
| Hazard statements | H225 - H290 - H315 - H319 - H335 - H351 |
| Precautionary statements | P202 - P210 - P233 - P303 + P361 + P353 - P305 + P351 + P338 - P308 + P313 |
| Hazard Codes | F,Xn |
| Risk Statements | 11-19-36/37/38-40 |
| Safety Statements | 9-16-26-33-36/37-60 |
| RIDADR | UN 2924 8(3) / PGII |
| WGK Germany | WGK 2 |
| Flash Point(F) | 62.6 °F - closed cup |
| Flash Point(C) | 17 °C - closed cup |
| Supplemental Hazard Statements | EUH019 |
| Density | 1.05 g/mL at 25 °C |
| UNSPSC | 12352301 |