Tetrahydrofuran
SIGALD/360589 - contains 250 ppm BHT as inhibitor, ACS reagent, ≥99.0%
Synonym: THF; Butylene oxide; Oxolane; Tetramethylene oxide
CAS Number: 109-99-9
Empirical Formula (Hill Notation): C4H8O
Molecular Weight: 72.11
EC Number: 203-726-8
MDL Number: MFCD00005356
Linear Formula: C4H8O
Product Type: Chemical
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: 360589-1L.
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: 360589-500ML.
| assay | ≥99.0% |
| autoignition temp. | 610 °F |
| bp | 65-67 °C (lit.) |
| color | APHA: ≤20 |
| contains | 250 ppm BHT as inhibitor |
| density | 0.889 g/mL at 25 °C (lit.) |
| evapn. residue | ≤0.03% |
| expl. lim. | 1.8-11.8 % |
| form | liquid |
| grade | ACS reagent |
| impurities | ≤0.015% peroxide (as H2O2) |
| ≤0.05% water | |
| InChI | 1S/C4H8O/c1-2-4-5-3-1/h1- |
| InChI key | WYURNTSHIVDZCO-UHFFFAOYSA |
| mp | −108 °C (lit.) |
| pH | ~7 |
| Quality Level | 200  |
| refractive index | n |
| SMILES string | C1CCOC1 |
| solubility | water: soluble |
| technique(s) | HPLC: suitable |
| vapor density | 2.5 (vs air) |
| vapor pressure | 114 mmHg ( 15 °C) |
| 143 mmHg ( 20 °C) |
| Application: | Tetrahydrofuran (THF) is used as a solvent in the following processes: • Organic synthesis a) Grignard b) Organometallic compounds c) Reformatsky d) Lithiation e) Hydride reduction f) Metal-catalyzed coupling (Heck, Stile, Suzuki) g) Lewis acid mediated reactions • Crystallization • Polymerization. Ex. RAFT (Reversible Addition-Fragmentation Chain Transfer) polymerization of p-acetoxystyrene • Coatings • As an O-donor ligand to form coordination complexes • As mobile phase solvent in high-performance liquid chromatography |
| Features and Benefits: | ACS solvents meet or exceed the high standards of the American Chemical Society (ACS),with test specifications that are specialized to every compound. According to the American Chemical Society, ACS reagent grade implies that it is a substance of sufficient purity to be used in most chemical analyses or reactions. |
| General description: | Tetrahydrofuran (THF) is a heterocyclic compound (cyclic ether). It is colorless, has low viscosity, and good solubility in a wide range of solvents. It is widely used as a solvent in organic synthesis, being very popular in reactions with organometallic compounds and Grignard reagents. Due to organic peroxides formation on long term storage, THF is usually stabilized by adding butylated hydroxytoluene (BHT). BHT removes the free radicals required for the peroxide formation. |
| Other Notes: | Go to our Greener Alternative-2-Methyl Tetrahydrofuran - 155810 Go to our Greener Alternative-Cyclopentyl methylether - 675989 |
| Packaging: | 1, 6×1, 2.5, 4, 4×4 L in glass bottle |
| Packaging: | 18, 200 L in steel drum |
| Packaging: | 500, 6×500 mL in glass bottle |
| Symbol |    GHS02,GHS07,GHS08 |
| Signal word | Danger |
| Hazard statements | H225 - H302 - H319 - H335 - H336 - H351 |
| Precautionary statements | P201 - P202 - P210 - P301 + P312 - P305 + P351 + P338 - P308 + P313 |
| Hazard Codes | F,Xn |
| Risk Statements | 11-19-36/37-40 |
| Safety Statements | 13-16-29-33-36-37-46 |
| RIDADR | UN 2056 3 / PGII |
| WGK Germany | WGK 1 |
| Flash Point(F) | -6.2 °F - closed cup |
| Flash Point(C) | -21.2 °C - closed cup |
| Supplemental Hazard Statements | EUH018 - EUH019 |
| Purity | ≥99.0% |
| bp | 65-67 °C (lit.) |
| mp | −108 °C (lit.) |
| Density | 0.889 g/mL at 25 °C (lit.) |
| Refractive Index | n |
| UNSPSC | 12191501 |