Ruthenium Red

SIGMA/00541 - for microscopy, 85.0-115.0% (calc. on dry basis, AT)

Synonym: Ammoniated ruthenium oxychloride

CAS Number: 11103-72-3
Empirical Formula (Hill Notation): H₄₂Cl₆N₁₄O₂Ru₃
Molecular Weight: 786.35
MDL Number: MFCD00011479
Linear Formula: [(NH₃)₅RuORu(NH₃)₄ORu(NH₃)₅]Cl₆
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-00541-1G	1 g	$264.00 1/EAAdd To Favorites		Add To Favorites
45-00541-5G	5 g	$889.00 1/EAAdd To Favorites		Add To Favorites

ε_max	≥150 at 529-539 nm
application(s)	diagnostic assay manufacturing hematology histology
assay	85.0-115.0% (calc. on dry basis, AT)
form	powder
grade	for microscopy
impurities	~5% water
InChI	1S/6ClH.14H3N.2O.3Ru/h61H;141H3;;;;;/q;;;;;;;;;;;;;;;;;;;;;;3*+2/p-6
InChI key	ZXYSDUPLHOJIOR-UHFFFAOYSA-H
Quality Level	100
SMILES string	N.N.N.N.N.N.N.N.N.N.N.N.N.N.[Cl-].[Cl-].[Cl-].[Cl-].[Cl-].[Cl-].[Ru++]O[Ru++]O[Ru++]
solubility	water: 10 mg/mL, clear to turbid
storage temp.	room temp

Application:	Inhibits mitochondrial Ca²⁺ uniporter; capsaicin antagonist; blocks VR1 vanilloid receptor-coupled ion channels.
Application:	Ruthenium red is suitable for use in light microscopy to stain pectins. It is also used to stain glycosaminoglycans by employing a two-color staining method with alcian blue. It serves as a typical basic dye at a higher pH that stains nuclei, Nissl substance, cartilage matrix, and mast cell granules. Other applications involving light microscopy include staining resin-embedded material. Ruthenium red is an important component of fixatives of the bacterial glycocalyx.
Biochem/physiol Actions:	Ruthenium red inhibits mitochondrial Ca2+ uniporter. It is a known capsaicin antagonist. Additionally, it is known to block VR1 vanilloid receptor-coupled ion channels.
General description:	Ruthenium red is an inorganic cationic dye. It is also known as ammoniated ruthenium oxychloride. It is a large coordination complex consisting of three metal atoms connected by bridging oxygens, in addition to multiple amine ligands.