Cycloheximide
SIGMA/01810 - ≥95% (HPLC)
Synonym: 3-
CAS Number: 66-81-9
Empirical Formula (Hill Notation): C15H23NO4
Molecular Weight: 281.35
EC Number: 200-636-0
MDL Number: MFCD00082346
Linear Formula: C15H23NO4
Product Type: Chemical
| antibiotic activity spectrum | fungi |
| yeast | |
| assay | ≥95% (HPLC) |
| biological source | microbial |
| color | white to light beige |
| form | powder or crystals |
| InChI | 1S/C15H23NO4/c1-8-3-9(2)1 |
| InChI key | YPHMISFOHDHNIV-FSZOTQKASA |
| mode of action | protein synthesis | interferes |
| mp | 110-120 °C |
| Quality Level | 200  |
| Application: | Cyclohexamide (CHX) is widely used for selection of CHX-resistant strains of yeast and fungi, controlled inhibition of protein synthesis for detection of short-lived proteins, super-induction of protein expression, and apoptosis induction or facilitation of apoptosis induction by death receptors. It has been shown to selectively clear macrophages in atherosclerotic plaques, activate cumulus-free equine oocytes, and to have neuroprotective properties. |
| Biochem/physiol Actions: | Cyclohexamide inhibits protein biosynthesis in eukaryotic cells by binding with the 80S ribosome. |
| Biochem/physiol Actions: | Cycloheximide (CHX) is an antibiotic produced by Strptomyces sp.. Its main biological activity is translation inhibition in eukaryotes resulting in cell growth arrest and cell death. CHX is widely used for selection of CHX-resistant strains of yeast and fungi, controlled inhibition of protein synthesis for detection of short-lived proteins and super-induction of protein expression, and apoptosis induction or facilitation of apoptosis induction by death receptors. |
| Other Notes: | Conditions for safe storage, including any incompatibilities. Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place. |
| Packaging: | 1G, 5G |
| Symbol |    GHS06,GHS08,GHS09 |
| Signal word | Danger |
| Hazard statements | H300 - H341 - H360D - H411 |
| Precautionary statements | P201 - P273 - P301 + P310 + P330 |
| Hazard Codes | T+,N |
| Risk Statements | 61-28-38-51/53-68 |
| Safety Statements | 53-45-61 |
| RIDADR | UN2811 - class 6.1 - PG 2 - EHS - Toxic solids, organic, n.o.s., |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥95% (HPLC) |
| mp | 110-120 °C |
| UNSPSC | 51101500 |