Catalase from Corynebacterium glutamicum

SIGMA/02071 - solution, deep brown, ≥500000 U/mL

CAS Number: 9001-05-2
MDL Number: MFCD00081483
Product Type: Chemical

biological source	bacterial (Corynebacterium glutamicum)
color	deep brown
concentration	≥500000 U/mL
form	solution
InChI	1S/C9H10O3/c1-2-12-9(11)7-3-5-8(10)6-4-7/h3-6,10H,2H2,1H3
InChI key	NUVBSKCKDOMJSU-UHFFFAOYSA-N
Quality Level	200
shipped in	wet ice
storage temp.	2-8°C

Application:	Catalase from Corynebacterium glutamicum has been used to identify and characterize purified bacterial peptide (PPBP) produced from Bacillus thuringiensis. It has also been used to study its inhibition by nitric oxide.
Biochem/physiol Actions:	Catalase is an antioxidant enzyme that plays a role in alleviating oxidative stress by the removal of hydrogen peroxide to produce oxygen and water. Lower levels of catalase lead to several age-related disorders including hypertension, anemia, vitiligo, Parkinson′s disease, Alzheimer′s disease, schizophrenia, bipolar disorders, diabetes mellitus, and cancer.
General description:	Catalase is ubiquitously found in animals, plants, fungi, and humans. It is made up of looped polypeptide chains that are arranged as tetramers or dimers and a core, that contains iron or manganese ions. Catalase can be differentiated into two types such as heme-containing (type I), which possesses an iron-porphyrin cofactor and a non-heme-containing (type II), which possesses a dinuclear manganese active site.
Physical form:	contains ~30% glycerol, 10% ethanol
Unit Definition:	1 U corresponds to the amount of enzyme which decomposes 1 μmol H₂O₂ per minute at pH 7.0 and 25°C