Propyl gallate
SIGMA/02370 - for microscopy, ≥98.0% (HPLC)
Synonym: 3,4,5-
CAS Number: 121-79-9
Empirical Formula (Hill Notation): C10H12O5
Molecular Weight: 212.20
EC Number: 204-498-2
MDL Number: MFCD00002196
Linear Formula: 3,4,5-(HO)3C6H2CO2CH2CH2CH3
Product Type: Chemical
| application(s) | diagnostic assay manufacturing hematology histology |
| assay | ≥98.0% (HPLC) |
| density | 1.21 g/cm3 |
| form | powder |
| grade | for microscopy |
| InChI | 1S/C10H12O5/c1-2-3-15-10( |
| InChI key | ZTHYODDOHIVTJV-UHFFFAOYSA |
| mp | 146-149 °C (lit.) |
| pH range | 5.7-6.3 |
| Quality Level | 100  |
| SMILES string | CCCOC(=O)c1cc(O)c(O)c(O)c |
| Application: | Propyl gallate is used as an anti-fade reagent in fluorescence microscopy to reduce photobleaching of fluorescent probes. |
| Application: | Used as an anti-fade reagent in fluorescence microscopy to reduce photobleaching of fluorescent probes such as rhodamine and fluorescein. |
| Biochem/physiol Actions: | An antioxidant that exhibits antimicrobial activity. Propyl gallate has been reported to be an effective antioxidant-based hepatoprotector, both in vitro and in vivo. It has also been shown to prevent neuronal apoptosis and block the death of neurons exposed to FeSO4/GA as well as partially protect endothelial cells against TNF-induced apoptosis. |
| Biochem/physiol Actions: | An antioxidant that exhibits antimicrobial activity. Propyl gallate has been reported to be an effective antioxidant-based hepatoprotector, both in vitro and in vivo. It has also been shown to prevent neuronal apoptosis and block the death of neurons exposed to FeSO4/GA as well as partially protect endothelial cells against TNF-induced apoptosis. However, propyl gallate induced single strand breaks in DNA at concentrations higher than 0.25 μM when it was combined with copper concentrations at 5 μM and above. Another report, however, found that incubation of isolated rat hepatocytes with propyl gallate at concentrations of >1 mM induced cell killing, whereas, a lower concentration of propyl gallate > 0.5 mM resulted in a ladder formation of soluble low-molecular weight DNA fragments, characteristic of apoptosis. |
| Reconstitution: | Prepare a 0.1M solution in glycerol:PBS (9:1) |
| Symbol |    GHS05,GHS07,GHS09 |
| Signal word | Danger |
| Hazard statements | H302 - H317 - H318 - H410 |
| Precautionary statements | P261 - P273 - P280 - P301 + P312 - P302 + P352 - P305 + P351 + P338 |
| Hazard Codes | Xn |
| Risk Statements | 22-43 |
| Safety Statements | 24-37 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 2 |
| Flash Point(F) | 368.6 °F - closed cup |
| Flash Point(C) | 187 °C - closed cup |
| Purity | ≥98.0% (HPLC) |
| mp | 146-149 °C (lit.) |
| Density | 1.21 g/cm3 |
| UNSPSC | 12352200 |