N-Ethylmaleimide

SIGMA/04260 - purum p.a., ≥99.0% (HPLC)

Synonym: NEM

CAS Number: 128-53-0
Empirical Formula (Hill Notation): C₆H₇NO₂
Molecular Weight: 125.13
EC Number: 204-892-4
MDL Number: MFCD00005509
Linear Formula: C₆H₇NO₂
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-04260-5G-F	5 g	$92.80 1/EAAdd To Favorites	Add To Favorites
45-04260-25G-F	25 g	$294.00 1/EAAdd To Favorites	Add To Favorites

anion traces	chloride (Cl^-): ≤50 mg/kg
	sulfate (SO₄^2-): ≤100 mg/kg
assay	≥99.0% (HPLC)
bp	210 °C (lit.)
cation traces	Ca: ≤50 mg/kg
	Cd: ≤50 mg/kg
	Co: ≤50 mg/kg
	Cu: ≤50 mg/kg
	Fe: ≤50 mg/kg
	K: ≤100 mg/kg
	Na: ≤100 mg/kg
	Ni: ≤50 mg/kg
	Pb: ≤50 mg/kg
	Zn: ≤50 mg/kg
grade	purum p.a.
ign. residue	≤0.05%
InChI	1S/C6H7NO2/c1-2-7-5(8)3-4-6(7)9/h3-4H,2H2,1H3
InChI key	HDFGOPSGAURCEO-UHFFFAOYSA-N
mp	43-46 °C
	43-46 °C (lit.)
Quality Level	200
SMILES string	CCN1C(=O)C=CC1=O
storage temp.	2-8°C

Application:	N-Ethylmaleimide has been used to measure low molecular weight thiols bound to plasma proteins.
Application:	Reagent for the covalent modification of cysteine residues in proteins.
Biochem/physiol Actions:	Augments currents from native M-channels in sympathetic neurons and acts as an opener for KCNQ2, KCNQ4 and KCNQ5 channels.
Biochem/physiol Actions:	Sulfhydryl alkylating agent that inactivates NADP-dependent isocitrate dehydrogenase and many endonucleases.

Symbol	GHS05,GHS06
Signal word	Danger
Hazard statements	H300 - H311 - H314 - H317
Precautionary statements	P260 - P270 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
Hazard Codes	T+
Risk Statements	21-28-34-43
Safety Statements	26-28-36/37/39-45
RIDADR	UN 2928 8(6.1) / PGII
WGK Germany	WGK 3
Flash Point(F)	163.2 °F
Flash Point(C)	72.9 °C

Purity	≥99.0% (HPLC)
bp	210 °C (lit.)
mp	43-46 °C (lit.); 43-46 °C
Storage Temp.	2-8°C
UNSPSC	12352209