Antipain

SIGMA/10791 - >50000 U/mg

Synonym: [(S)-1-Carboxy-2-phenylethyl]carbamoyl-L-arginyl-L-valyl-argininal

CAS Number: 37691-11-5
Empirical Formula (Hill Notation): C₂₇H₄₄N₁₀O₆
Molecular Weight: 604.70
EC Number: 253-631-0
MDL Number: MFCD00135959
Linear Formula: C₂₇H₄₄N₁₀O₆
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-10791-5MG	5 mg	$130.00 1/EAAdd To Favorites	Add To Favorites
45-10791-25MG	25 mg	$463.00 1/EAAdd To Favorites	Add To Favorites

InChI	1S/C27H44N10O6/c1-16(2)21(23(40)34-18(15-38)10-6-12-32-25(28)29)37-22(39)19(11-7-13-33-26(30)31)35-27(43)36-20(24(41)42)14-17-8-4-3-5-9-17/h3-5,8-9,15-16,18-21H,6-7,10-14H2,1-2H3,(H,34,40)(H,37,39)(H,41,42)(H4,28,29,32)(H4,30,31,33)(H2,35,36,43)/t18?,19-,20-,21-/m0/s1
InChI key	SDNYTAYICBFYFH-KTYMLHDXSA-N
mode of action	enzyme \| inhibits
Quality Level	100
SMILES string	[H]C(=O)C(CCCNC(N)=N)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)N[C@@H](Cc1ccccc1)C(O)=O)C(C)C
specific activity	>50000 U/mg
storage temp.	−20°C

Biochem/physiol Actions:	Inhibits serine/cysteine proteases and some trypsin-like proteases. Compare activity to that of leupeptin. Used to evaluate the role of proteases in cell transformations. Used to help identify new proteases.
Biochem/physiol Actions:	Reversible inhibitor of serine/cysteine proteases and some trypsin-like serine proteases. Its action resembles leupeptin; however, its plasmin inhibition is less and its cathepsin A inhibition is more than that observed with leupeptin. Chronic administration can reduce the frequency of chemically induced transformation in BALB/c-/3T3 cells.
General description:	Chemical structure: peptide
Other Notes:	Protease inhibitor
Packaging:	Bottomless glass bottle. Contents are inside inserted fused cone.
Unit Definition:	1 U corresponds to the amount of inhibitor which reduces the trypsin activity by 1 BAEE-U. (1 BAEE-U is the amount of enzyme which increases the absorbance at 253 nm by 0.001 per minute at pH 7.6 and 25°C; BAEE, Cat. No. 12880, as substrate)

Symbol	GHS07
Signal word	Warning
Hazard statements	H302
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

activity	specific activity: >50000 U/mg
Storage Temp.	−20°C
UNSPSC	12352202