Antipain
SIGMA/10791 - >50000 U/mg
Synonym: [(S)
CAS Number: 37691-11-5
Empirical Formula (Hill Notation): C27H44N10O6
Molecular Weight: 604.70
EC Number: 253-631-0
MDL Number: MFCD00135959
Linear Formula: C27H44N10O6
Product Type: Chemical
| InChI | 1S/C27H44N10O6/c1-16(2)21 |
| InChI key | SDNYTAYICBFYFH-KTYMLHDXSA |
| mode of action | enzyme | inhibits |
| Quality Level | 100  |
| SMILES string | [H]C(=O)C(CCCNC(N)=N)NC(= |
| specific activity | >50000 U/mg |
| storage temp. | −20°C |
| Biochem/physiol Actions: | Inhibits serine/cysteine proteases and some trypsin-like proteases. Compare activity to that of leupeptin. Used to evaluate the role of proteases in cell transformations. Used to help identify new proteases. |
| Biochem/physiol Actions: | Reversible inhibitor of serine/cysteine proteases and some trypsin-like serine proteases. Its action resembles leupeptin; however, its plasmin inhibition is less and its cathepsin A inhibition is more than that observed with leupeptin. Chronic administration can reduce the frequency of chemically induced transformation in BALB/c-/3T3 cells. |
| General description: | Chemical structure: peptide |
| Other Notes: | Protease inhibitor |
| Packaging: | Bottomless glass bottle. Contents are inside inserted fused cone. |
| Unit Definition: | 1 U corresponds to the amount of inhibitor which reduces the trypsin activity by 1 BAEE-U. (1 BAEE-U is the amount of enzyme which increases the absorbance at 253 nm by 0.001 per minute at pH 7.6 and 25°C; BAEE, Cat. No. 12880, as substrate) |
| Symbol |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| activity | specific activity: >50000 U/mg |
| Storage Temp. | −20°C |
| UNSPSC | 12352202 |