CD16 (SP175) Rabbit Monoclonal Antibody

SIGMA/116R-1

Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-116R-14	0.1 mL	$0.00 1/EA CALL FOR PRICEAdd To Favorites	Add To Favorites
45-116R-15	0.5 mL	$0.00 1/EA CALL FOR PRICEAdd To Favorites	Add To Favorites
45-116R-16	1 mL	$0.00 1/EA CALL FOR PRICEAdd To Favorites	Add To Favorites
45-116R-17	1 mL	$0.00 1/EA CALL FOR PRICEAdd To Favorites	Add To Favorites
45-116R-18	7 mL	$0.00 1/EA CALL FOR PRICEAdd To Favorites	Add To Favorites

Immunohistochemistry CD16 (SP175) on acute myeloid leukemia

antibody form	culture supernatant
antibody product type	primary antibodies
biological source	rabbit
clone	SP175, monoclonal
conjugate	unconjugated
control	tonsil
description	For In Vitro Diagnostic Use in Select Regions (See Chart)
form	buffered aqueous solution
isotype	IgG
manufacturer/tradename	Cell Marque^™
packaging	bottle of 1.0 mL predilute (116R-17)
	bottle of 7.0 mL predilute (116R-18)
	vial of 0.1 mL concentrate (116R-14)
	vial of 0.5 mL concentrate (116R-15)
	vial of 1.0 mL concentrate (116R-16)
Quality Level	100
	500
shipped in	wet ice
species reactivity	human
storage temp.	2-8°C
technique(s)	immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100
visualization	cytoplasmic, membranous

General description:

CD16 is a biomarker associated with monocytes and natural killer (NK) cells of the lymphoid lineage. Anti-CD16 immunohistochemistry is useful in differentially diagnosing hepatosplenic gamma delta T-cell lymphoma and gamma delta T-cell large granular lymphocyte leukemia from other peripheral T-cell lymphomas, such as mucosal and cutaneous gamma delta T-cell lymphoma. It is reported that 58% of hepatosplenic gamma delta T-cell lymphomas express CD16, and 86% of gamma delta T-cell large granular lymphocyte leukemias are immunoreactive with anti-CD16. Mucosal and cutaneous gamma delta T-cell lymphomas usually do not express CD16 antigen. A significant decrease can be seen in the number of granulocytes expressing CD16 in chronic myelomonocytic leukemia compared to chronic myelogenous leukemia and control bone marrow biopsy, probably related to dysgranulopoiesis. Bone marrow biopsy immunohistochemistry can be helpful in CMML by identifying both the monocyte expansion and the dysgranulopoiesis with anti-CD16.

General description:

CD16 is a receptor on monocytes and natural killer (NK) cells, which facilitates antibody-dependent cellular cytotoxicity. CD16 is a useful marker in NK neoplasms and in certain T-cell neoplasms such as T-cell large granular lymphocytic leukemia.

Legal Information:

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

Linkage:

CD16 Positive Control Slides, Product No. 116S External link

, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Other Notes:

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Physical form:

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Preparation Note:

Download the IFU specific to your product lot and format External link

Note: This requires a keycode which can be found on your packaging or product label.

Quality:

IVD

RUO

Storage Temp.	2-8°C
UNSPSC	12352203