Bacitracin

SIGMA/11702 - from Bacillus licheniformis, ≥65 IU/mg

Synonym: Altracin; Bacitracin A

CAS Number: 1405-87-4
Empirical Formula (Hill Notation): C₆₆H₁₀₃N₁₇O₁₆S
Molecular Weight: 1422.69
EC Number: 215-786-2
MDL Number: MFCD00062640
Linear Formula: C₆₆H₁₀₃N₁₇O₁₆S
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-11702-5G	5 g	$101.00 1/EAAdd To Favorites		Add To Favorites
45-11702-25G	25 g	$373.00 1/EAAdd To Favorites		Add To Favorites

antibiotic activity spectrum	Gram-positive bacteria
biological source	Bacillus licheniformis
color	white to pale buff
form	powder
InChI	1S/C66H103N17O16S/c1-9-35(6)52(69)66-81-48(32-100-66)63(97)76-43(26-34(4)5)59(93)74-42(22-23-50(85)86)58(92)83-53(36(7)10-2)64(98)75-40-20-15-16-25-71-55(89)46(29-49(68)84)78-62(96)47(30-51(87)88)79-61(95)45(28-39-31-70-33-72-39)77-60(94)44(27-38-18-13-12-14-19-38)80-65(99)54(37(8)11-3)82-57(91)41(21-17-24-67)73-56(40)90/h12-14,18-19,31,33-37,40-48,52-54H,9-11,15-17,20-30,32,67,69H2,1-8H3,(H2,68,84)(H,70,72)(H,71,89)(H,73,90)(H,74,93)(H,75,98)(H,76,97)(H,77,94)(H,78,96)(H,79,95)(H,80,99)(H,82,91)(H,83,92)(H,85,86)(H,87,88)/t35?,36-,37-,40-,41+,42+,43-,44+,45-,46-,47+,48?,52?,53-,54-/m0/s1
InChI key	CLKOFPXJLQSYAH-RNHDWVCBSA-N
mode of action	cell wall synthesis \| interferes
Quality Level	200
SMILES string	[H]N1[C@@H](Cc2cnc[nH]2)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)C3CSC(=N3)C(N)C(C)CC)[C@@H](C)CC)C(=O)N[C@H](CCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@H](Cc4ccccc4)C1=O
specific activity	≥65 IU/mg
storage temp.	2-8°C

Application:	Bacitracin is used to study disruption of bacterial cell wall synthesis at the level of peptidoglycan biosynthesis and isoprenyl metabolism. It is also used to study the biosynthesis of sterols and squalene. Bacitracin has been used: • as a protease inhibitor • as a control antibiotic • for the calibration in size exclusion chromatography
Biochem/physiol Actions:	Bacitracin has been shown to decrease vancomycin-resistant Enterococcus faecium population in intestine.
Biochem/physiol Actions:	Bacitracin is a peptide antibiotic. Antimicrobial spectrum: Gram-positive bacteria. Mode of Action: Inhibits bacterial cell wall synthesis by inhibiting dephosphorylation of lipid pyrophosphate.
General description:	Chemical structure: peptide
Other Notes:	Keep container tightly closed in a dry and well-ventilated place. Moisture sensitive. Keep in a dry place.
Packaging:	5G, 25 G