Bilirubin
SIGMA/14370 - purum, ≥95.0% (UV)
Synonym: Bile pigment; Hemetoidin
CAS Number: 635-65-4
Empirical Formula (Hill Notation): C33H36N4O6
Molecular Weight: 584.66
EC Number: 211-239-7
MDL Number: MFCD00005499
Linear Formula: C33H36N4O6
Product Type: Chemical
| assay | ≥95.0% (UV) |
| form | powder |
| grade | purum |
| ign. residue | ≤0.5% |
| InChI | 1S/C33H36N4O6/c1-7-20-19( |
| InChI key | BPYKTIZUTYGOLE-IFADSCNNSA |
| Quality Level | 100  |
| SMILES string | CC1=C(C=C)C(NC1=O)=Cc2[ |
| Analysis Note: | λmax. ∼453 nm, mol. absorption >56100 (chloroform) |
| Application: | Bilirubin has been used as an interfering substance for in vitro interference and stability tests for myoglobin, creatine kinase-MB (CK-MB), and troponin-I. It has also been used as an interfering agent to test the effectiveness of the Heparin Red kit in the detection of various heparins. |
| Biochem/physiol Actions: | Bilirubin is an active oxidative DNA cleaving agent as well as an effective antioxidant agent, a hydroxyl radical quencher. This bile pigment has both antioxidant and toxic properties. It is a natural inhibitor of vascular smooth muscle cell proliferation (VSMCs). It displays anti-inflammatory and anti-proliferative properties when used as a therapeutic agent in lung/vascular diseases. Serum bilirubin concentration slightly above the normal levels have shown a lesser incidence of heart disease. It is a potential therapeutic agent in heart transplantation and T-cell mediated immune disorders. |
| Biochem/physiol Actions: | Well over 99% of total bilirubin is transported as a conjugate with albumin. Abnormally high levels of bilirubin can cause severe neurological damage, but mildly elevated levels are linked to protection from oxidative stress. |
| General description: | Bilirubin, a heme catabolism end-product is produced by the reduction of its metabolic precursor biliverdin by the action of enzyme biliverdin reductase. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 2 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥95.0% (UV) |
| UNSPSC | 12352202 |