Bilirubin

SIGMA/14370 - purum, ≥95.0% (UV)

Synonym: Bile pigment; Hemetoidin

CAS Number: 635-65-4
Empirical Formula (Hill Notation): C₃₃H₃₆N₄O₆
Molecular Weight: 584.66
EC Number: 211-239-7
MDL Number: MFCD00005499
Linear Formula: C₃₃H₃₆N₄O₆
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-14370-1G	1 g	No Price

assay	≥95.0% (UV)
form	powder
grade	purum
ign. residue	≤0.5%
InChI	1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/b26-13-,27-14-
InChI key	BPYKTIZUTYGOLE-IFADSCNNSA-N
Quality Level	100
SMILES string	CC1=C(C=C)C(NC1=O)=Cc2[nH]c(Cc3[nH]c(C=C4/NC(=O)C(C=C)=C4C)c(C)c3CCC(O)=O)c(CCC(O)=O)c2C

Analysis Note:	λ_max. ∼453 nm, mol. absorption >56100 (chloroform)
Application:	Bilirubin has been used as an interfering substance for in vitro interference and stability tests for myoglobin, creatine kinase-MB (CK-MB), and troponin-I. It has also been used as an interfering agent to test the effectiveness of the Heparin Red kit in the detection of various heparins.
Biochem/physiol Actions:	Bilirubin is an active oxidative DNA cleaving agent as well as an effective antioxidant agent, a hydroxyl radical quencher. This bile pigment has both antioxidant and toxic properties. It is a natural inhibitor of vascular smooth muscle cell proliferation (VSMCs). It displays anti-inflammatory and anti-proliferative properties when used as a therapeutic agent in lung/vascular diseases. Serum bilirubin concentration slightly above the normal levels have shown a lesser incidence of heart disease. It is a potential therapeutic agent in heart transplantation and T-cell mediated immune disorders.
Biochem/physiol Actions:	Well over 99% of total bilirubin is transported as a conjugate with albumin. Abnormally high levels of bilirubin can cause severe neurological damage, but mildly elevated levels are linked to protection from oxidative stress.
General description:	Bilirubin, a heme catabolism end-product is produced by the reduction of its metabolic precursor biliverdin by the action of enzyme biliverdin reductase.