Blasticidine S hydrochloride

SIGMA/15205

Synonym: Blasticidin S

CAS Number: 3513-03-9
Empirical Formula (Hill Notation): C₁₇H₂₆N₈O₅ · HCl
Molecular Weight: 458.90
MDL Number: MFCD02091640
Linear Formula: C₁₇H₂₆N₈O₅ · HCl
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-15205-25MG	25 mg	$208.00 1/EAAdd To Favorites		Add To Favorites
45-15205-100MG	100 mg	$572.00 1/EAAdd To Favorites		Add To Favorites

antibiotic activity spectrum	fungi
application(s)	agriculture environmental
color	white to off-white
form	powder
InChI	1S/C17H26N8O5.ClH/c1-24(16(20)21)6-4-9(18)8-12(26)22-10-2-3-13(30-14(10)15(27)28)25-7-5-11(19)23-17(25)29;/h2-3,5,7,9-10,13-14H,4,6,8,18H2,1H3,(H3,20,21)(H,22,26)(H,27,28)(H2,19,23,29);1H/t9-,10+,13-,14+;/m1./s1
InChI key	YQXYQOXRCNEATG-ZAYJLJTISA-N
mode of action	protein synthesis \| interferes
Quality Level	200
shipped in	dry ice
SMILES string	Cl[H].CN(CC[C@@H](N)CC(=O)N[C@H]1C=C[C@@H](O[C@@H]1C(O)=O)N2C=CC(N)=NC2=O)C(N)=N
solubility	acetic acid: water: soluble, clear, colorless
storage temp.	−20°C

Application:	Blasticidin S is used as a selection agent for transformed cells that contain the resistance genes bls, bsr, or BSD. Blasticidiin S has been used to select HEK293-T cells with TLR-2 constructs and HEK-D5 cells . It is also used to study protein synthesis at the level of peptide bond formation.
Biochem/physiol Actions:	Blasticidin S inhibits hydrolysis of peptidyl-tRNA induced by release factors. It enhances the binding of tRNA to the large subunit of ribosomes and to an extent inhibits peptide bond formation.
General description:	Blasticidin S belongs to the aminoacylnucleoside class of antibiotics. It inhibits protein synthesis in bacteria and eukaryotes. It also has fungicidal properties and prevents rice blast disease.
General description:	Chemical structure: nucleoside
Other Notes:	Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place. Storage class (TRGS 510): Non-combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials
Packaging:	Bottomless glass bottle. Contents are inside inserted fused cone.

Symbol	GHS06
Signal word	Danger
Hazard statements	H300
Precautionary statements	P264 - P270 - P301 + P310 + P330 - P405 - P501
Hazard Codes	T+
Risk Statements	28
Safety Statements	28-36/37-45
RIDADR	UN 2811 6.1 / PGII
WGK Germany	WGK 2
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable