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Blasticidine S hydrochloride

SIGMA/15205

Synonym: Blasticidin S

CAS Number: 3513-03-9
Empirical Formula (Hill Notation): C17H26N8O5 · HCl
Molecular Weight: 458.90
MDL Number: MFCD02091640
Linear Formula: C17H26N8O5 · HCl
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-15205-25MG 25 mg
 $208.00
1/EA		 Add To Favorites
45-15205-100MG 100 mg
 $572.00
1/EA		 Add To Favorites

 

antibiotic activity spectrum fungi
application(s) agriculture
environmental
color white to off-white
form powder
InChI 1S/C17H26N8O5.ClH/c1-24(16(20)21)6-4-9(18)8-12(26)22-10-2-3-13(30-14(10)15(27)28)25-7-5-11(19)23-17(25)29;/h2-3,5,7,9-10,13-14H,4,6,8,18H2,1H3,(H3,20,21)(H,22,26)(H,27,28)(H2,19,23,29);1H/t9-,10+,13-,14+;/m1./s1
InChI key YQXYQOXRCNEATG-ZAYJLJTISA-N
mode of action protein synthesis | interferes
Quality Level 200 
shipped in dry ice
SMILES string Cl[H].CN(CC[C@@H](N)CC(=O)N[C@H]1C=C[C@@H](O[C@@H]1C(O)=O)N2C=CC(N)=NC2=O)C(N)=N
solubility acetic acid: water: soluble, clear, colorless
storage temp. −20°C
Application: Blasticidin S is used as a selection agent for transformed cells that contain the resistance genes bls, bsr, or BSD. Blasticidiin S has been used to select HEK293-T cells with TLR-2 constructs and HEK-D5 cells . It is also used to study protein synthesis at the level of peptide bond formation.
Biochem/physiol Actions: Blasticidin S inhibits hydrolysis of peptidyl-tRNA induced by release factors. It enhances the binding of tRNA to the large subunit of ribosomes and to an extent inhibits peptide bond formation.
General description: Blasticidin S belongs to the aminoacylnucleoside class of antibiotics. It inhibits protein synthesis in bacteria and eukaryotes. It also has fungicidal properties and prevents rice blast disease.
General description: Chemical structure: nucleoside
Other Notes: Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place. Storage class (TRGS 510): Non-combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials
Packaging: Bottomless glass bottle. Contents are inside inserted fused cone.
Storage Temp. −20°C
UNSPSC 51102829

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