Poloxamer 188

SIGMA/15759

Synonym: Poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol); Lutrol F68

CAS Number: 9003-11-6
MDL Number: MFCD00082049
Product Type: Chemical

CMC	0.48 mM
color	APHA: ≤120, 50/50 in CH₃OH
composition	oxyethylene, 79.9-83.7%
form	solid
HLB	>24
ign. residue	≤0.30%
impurities	≤0.25% ethylene glycol and diethylene glycol
	≤0.4% total ash
	≤1 ppm ethylene oxide
	≤1.0% water
	≤2 ppm arsenic traces
	≤20 ppm heavy metals
	≤5 ppm dioxan
	≤5 ppm propylene oxide
	50-150 ppm butylhydroxytoluene
InChI	1S/C3H6O.C2H4O/c1-3-2-4-3;1-2-3-1/h3H,2H2,1H3;1-2H2
InChI key	RVGRUAULSDPKGF-UHFFFAOYSA-N
mol wt	~7680-9510 g/mol
pH	5.0-7.5 (100 g/L in H₂O)
	6.0-7.5 (25 g/L in H₂O)
Quality Level	200
transition temp	cloud point >100 °C

Application:	Stabilizing Function of P 188 in Dermal Formulations: Examined for its stabilizing effects on industrial concentrates of dermal hesperidin smartCrystals, P 188 contributed to enhancing the long-term stability of the formulations, relevant for dermal therapeutic interventions (Romero et al., 2015 ).
Biochem/physiol Actions:	Poloxamer 188 is widely used as a thickening agent and gel binder.
Other Notes:	The Poloxamer 188 grades are poloxamers from the extensive line of block copolymers.

RIDADR	NONH for all modes of transport
WGK Germany	WGK 1
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

UNSPSC

12352104