Cobalt chloride 0.1 M solution

SIGMA/15862

Synonym: Cobalt(II)-chloride solution; Additive Screening Solution 24/Kit-No 78374

CAS Number: 7646-79-9
MDL Number: MFCD00010938
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-15862-1ML-F	1 mL	$75.70 1/EAAdd To Favorites	Add To Favorites

density	1.01 g/mL at 20 °C
InChI	1S/2ClH.Co/h2*1H;/q;;+2/p-2
InChI key	GVPFVAHMJGGAJG-UHFFFAOYSA-L
Quality Level	100
SMILES string	Cl[Co]Cl
storage temp.	2-8°C

Application:

Cobalt chloride 0.1M solution has been used to simulate hypoxic exposure and HIF-1 (hypoxia-inducible factor 1) expression in prostate cancer cells. It has been used to induce hypoxia in human intestinal epithelial cells.

Biochem/physiol Actions:

Cobalt chloride induces hypoxia condition in cells by upregulating hypoxia-inducible factor-1α (HIF-1α), erythropoietin and glycolytic enzymes. It is also responsible for mitochondrial DNA damage in rat neuronal PC12 cells. It is also responsible for the induction of apoptosis.
Cobalt chloride 0.1M solution is an additive screening solution of Additive Screening Kit. Additive Screen kit is designed to allow rapid and convenient evaluation of additives and their ability to influence the crystallization of the sample. The Additive Kit provides a tool for refining crystallization conditions.

Symbol	GHS08,GHS09
Signal word	Danger
Hazard statements	H317 - H334 - H341 - H350 - H360F - H411
Precautionary statements	P202 - P261 - P273 - P280 - P302 + P352 - P308 + P313
Hazard Codes	T,N
Risk Statements	49-60-42/43-51/53-68
Safety Statements	53-23-36/37-45-61
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Density	1.01 g/mL at 20 °C
Storage Temp.	2-8°C
UNSPSC	12352302