Cobalt chloride 0.1 M solution
SIGMA/15862
Synonym: Cobalt(II)-chloride solution; Additive Screening Solution 24/Kit-No 78374
CAS Number: 7646-79-9
MDL Number: MFCD00010938
Product Type: Chemical
| density | 1.01 g/mL at 20 °C |
| InChI | 1S/2ClH.Co/h2*1H;/q;;+2/p |
| InChI key | GVPFVAHMJGGAJG-UHFFFAOYSA |
| Quality Level | 100  |
| SMILES string | Cl[Co]Cl |
| storage temp. | 2-8°C |
| Application: | Cobalt chloride 0.1M solution has been used to simulate hypoxic exposure and HIF-1 (hypoxia-inducible factor 1) expression in prostate cancer cells. It has been used to induce hypoxia in human intestinal epithelial cells. |
| Biochem/physiol Actions: | Cobalt chloride induces hypoxia condition in cells by upregulating hypoxia-inducible factor-1α (HIF-1α), erythropoietin and glycolytic enzymes. It is also responsible for mitochondrial DNA damage in rat neuronal PC12 cells. It is also responsible for the induction of apoptosis. Cobalt chloride 0.1M solution is an additive screening solution of Additive Screening Kit. Additive Screen kit is designed to allow rapid and convenient evaluation of additives and their ability to influence the crystallization of the sample. The Additive Kit provides a tool for refining crystallization conditions. |
| Symbol |   GHS08,GHS09 |
| Signal word | Danger |
| Hazard statements | H317 - H334 - H341 - H350 - H360F - H411 |
| Precautionary statements | P202 - P261 - P273 - P280 - P302 + P352 - P308 + P313 |
| Hazard Codes | T,N |
| Risk Statements | 49-60-42/43-51/53-68 |
| Safety Statements | 53-23-36/37-45-61 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Density | 1.01 g/mL at 20 °C |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352200 |