Poloxamer 407
SIGMA/16758 - purified, non-ionic
Synonym: Poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol)
CAS Number: 9003-11-6
MDL Number: MFCD00082049
Product Type: Chemical
| cation traces | Al: ≤5 mg/kg |
| As: ≤0.05 mg/kg | |
| Ba: ≤5 mg/kg | |
| Bi: ≤5 mg/kg | |
| Ca: ≤50 mg/kg | |
| Cd: ≤5 mg/kg | |
| Co: ≤5 mg/kg | |
| Cr: ≤5 mg/kg | |
| Cu: ≤5 mg/kg | |
| Fe: ≤5 mg/kg | |
| K: ≤1000 mg/kg | |
| Li: ≤5 mg/kg | |
| Mg: ≤5 mg/kg | |
| Mn: ≤5 mg/kg | |
| Mo: ≤5 mg/kg | |
| Na: ≤50 mg/kg | |
| Ni: ≤5 mg/kg | |
| Pb: ≤5 mg/kg | |
| Sr: ≤5 mg/kg | |
| Zn: ≤5 mg/kg | |
| form | powder |
| impurities | ≤1.0% water |
| InChI | 1S/C3H6O.C2H4O/c1-3-2-4-3 |
| InChI key | RVGRUAULSDPKGF-UHFFFAOYSA |
| pH | 5.0-7.5 |
| quality | purified |
| Quality Level | 100  |
| solubility | soluble, clear, colorless |
| storage temp. | 2-8°C |
| suitability | no residue for filter test |
| UV absorption | λ: 260 nm Amax: ≤0.3 |
| λ: 280 nm Amax: ≤0..2 |
| Application: | Poloxamer 407 has been used: • as an inhibitor of lipoprotein lipase activity to assess hepatic very-low-density lipoprotein (VLDL)- triglyceride (TG) secretion in mice • for VLDL secretion assay in mice • to intraperitoneally inject the mice by dissolving in phosphate buffer saline (PBS) for hepatic triglyceride production |
| Biochem/physiol Actions: | Poloxamer 407 (P407) exhibits reversible gelation properties above a particular polymer concentration and temperature. Poloxamer 407-based sterile injectable formulations serve to be a good candidate for drug delivery. P407 thermo-responsive hydrogels are broadly used as mucosal drug delivery systems as they do not irritate the mucosal membranes. P407 is called an “inactive ingredient” by the U.S. Food and Drug Administration (FDA) for several drug products like oral solutions, suspensions, and inhalation formulations. |
| General description: | Poloxamer 407 is a water-soluble, non-ionic surfactant with low toxicity and good solubilizing capacity. This triblock copolymer is composed of a hydrophobic residue of polyoxypropylene (POP) flanked by two hydrophilic units of polyoxyethylene (POE). |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352104 |