1α,25-Dihydroxyvitamin D₃

SIGMA/17936 - ≥97.0% (HPLC)

Synonym: 1α,25-Dihydroxycholecalciferol; Calcitriol

CAS Number: 32222-06-3
Empirical Formula (Hill Notation): C₂₇H₄₄O₃
Molecular Weight: 416.64
EC Number: 250-963-8
MDL Number: MFCD00867079
Linear Formula: C₂₇H₄₄O₃
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-17936-100UG-F	100 µg	$899.00 1/EAAdd To Favorites		Add To Favorites
45-17936-1MG-F	1 mg	$2040.00 1/EAAdd To Favorites		Add To Favorites

assay	≥97.0% (HPLC)
color	white to off-white
form	crystals
InChI	1S/C27H44O3/c1-18(8-6-14-26(3,4)30)23-12-13-24-20(9-7-15-27(23,24)5)10-11-21-16-22(28)17-25(29)19(21)2/h10-11,18,22-25,28-30H,2,6-9,12-17H2,1,3-5H3/b20-10+,21-11-/t18-,22-,23-,24+,25+,27-/m1/s1
InChI key	GMRQFYUYWCNGIN-NKMMMXOESA-N
Quality Level	200
SMILES string	[H][C@@]1(CC[C@@]2([H])C(CCC[C@]12C)=CC=C3C[C@@H](O)C[C@H](O)C3=C)[C@H](C)CCCC(C)(C)O
storage temp.	−70°C

Application:	1α,25-Dihydroxyvitamin D₃ has been used to study its effect on transplantation success of human muscle precursor cells (hMPCs) in severe combined immunodeficient (SCID) mice in-vitro.
Biochem/physiol Actions:	1α,25-Dihydroxyvitamin D₃ modulates energy metabolism by facilitating various metabolic processes, such as Ca²⁺ signaling and modulation of glucocorticoids, by affecting adipocyte apoptosis and by regulating the expression and production of multiple cytokines. In addition, it also modulates phosphorus homeostasis through actions in the intestine, kidney and bone. 1α,25-Dihydroxyvitamin D₃ exhibits antiproliferative effects and is used as a potent therapeutic for human prostate cancer.
Biochem/physiol Actions:	Biologically active form of vitamin D₃in calcium absorption and deposition. 1α,25-Dihydroxyvitamin D₃ has widespread effects on cellular differentiation and proliferation, and can modulate immune responsiveness, and central nervous system function. Recent studies suggest that 1α,25-dihydroxyvitamin D₃ acts as a chemopreventive agent against several malignancies including cancers of the prostate and colon and shows synergy with other anticancer compounds.
General description:	1α,25-Dihydroxyvitamin D₃, also referred as calcitriol, is a calcitrophic hormone. It is the most biologically active metabolite of vitamin D produced in proximal tubular cells in the kidney.
Packaging:	1 mg in poly bottle
Packaging:	100 μg in poly bottle
Packaging:	Bottomless glass bottle. Contents are inside inserted fused cone.