25-Hydroxyvitamin D₃ monohydrate

SIGMA/17938 - ≥99.0% (HPLC)

Synonym: 25-Hydroxycholecalciferol

CAS Number: 63283-36-3
Empirical Formula (Hill Notation): C₂₇H₄₄O₂ · H₂O
Molecular Weight: 418.65
MDL Number: MFCD00867077
Linear Formula: C₂₇H₄₄O₂ · H₂O
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-17938-1MG	1 mg	$405.00 1/EAAdd To Favorites	Add To Favorites

assay	≥99.0% (HPLC)
biological source	synthetic
color	white to off-white
form	powder or crystals
InChI	1S/C27H44O2/c1-19-10-13-23(28)18-22(19)12-11-21-9-7-17-27(5)24(14-15-25(21)27)20(2)8-6-16-26(3,4)29/h11-12,20,23-25,28-29H,1,6-10,13-18H2,2-5H3/b21-11+,22-12-/t20-,23+,24-,25+,27-/m1/s1
InChI key	JWUBBDSIWDLEOM-DTOXIADCSA-N
Quality Level	200
shipped in	dry ice
SMILES string	[H][C@@]1(CC[C@@]2([H])C(CCC[C@]12C)=CC=C3C[C@@H](O)CCC3=C)[C@H](C)CCCC(C)(C)O
storage temp.	−20°C

Biochem/physiol Actions:

Cholecalciferol is an inactive form of vitamin D3 which undergoes various levels of hydroxylation to form active vitamin D3 analogs. 1α-Hydroxyvitamin D3 (alfacalcidol) is a synthetic analog that is metabolized to 1,25-dihydroxycholecalciferol, the biologically active form of vitamin D3. Other analogues of cholecalciferol result from different hydroxylations. 25-dihydroxycholecalciferol is a the major circulating form of vitamin D3 and a physiological precursor of 1α,25-Dihydroxycholecalciferol. The conversion is catalyzed by 25-Hydroxyvitamin D3 1-α-hydroxylase (VD3 1A hydroxylase) also known ascytochrome p450 27B1 (CYP27B1).

Packaging:

Bottomless glass bottle. Contents are inside inserted fused cone.

Symbol	GHS06,GHS08
Signal word	Danger
Hazard statements	H300 + H310 + H330 - H372
Precautionary statements	P262 - P280 - P301 + P310 + P330 - P302 + P352 + P310 - P304 + P340 + P310 - P314
Hazard Codes	T+
Risk Statements	24/25-26-48/25
Safety Statements	28-36/37-45
RIDADR	UN 2811 6.1 / PGII
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥99.0% (HPLC)
Storage Temp.	−20°C
UNSPSC	12352205