(24R)-24,25-Dihydroxyvitamin D₃

SIGMA/17943 - ≥98% (vitamin + pre-vitamin, HPLC)

Synonym: (24R)-,24,25-Dihydroxycholecalciferol; Secalciferol

CAS Number: 55721-11-4
Empirical Formula (Hill Notation): C₂₇H₄₄O₃
Molecular Weight: 416.64
MDL Number: MFCD00941417
Linear Formula: C₂₇H₄₄O₃
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-17943-100UG	100 µg	$1200.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (vitamin + pre-vitamin, HPLC)
biological source	synthetic
color	colorless to white
form	powder or crystals
InChI	1S/C27H44O3/c1-18-8-12-22(28)17-21(18)11-10-20-7-6-16-27(5)23(13-14-24(20)27)19(2)9-15-25(29)26(3,4)30/h10-11,19,22-25,28-30H,1,6-9,12-17H2,2-5H3/b20-10+,21-11-/t19-,22+,23-,24+,25-,27-/m1/s1
InChI key	FCKJYANJHNLEEP-XRWYNYHCSA-N
Quality Level	200
SMILES string	[H][C@@]1(CC[C@@]2([H])C(CCC[C@]12C)=CC=C3C[C@@H](O)CCC3=C)[C@H](C)CC[C@@H](O)C(C)(C)O
storage temp.	−20°C

Application:	(24R)-24,25-Dihydroxyvitamin D₃ has been used to assess its function(s) compared with that of 1α,25(OH)2D₃, during osteoblastic differentiation of primary human mesenchymal stem cells (hMSCs).
Biochem/physiol Actions:	(24R)-24,25-Dihydroxyvitamin D₃ plays an essential role in calcium and phosphorus homeostasis. (24R)-24,25-Dihydroxyvitamin D₃ along with 1α,25(OH)2D3 stimulates bone metabolism.
Biochem/physiol Actions:	Cholecalciferol is an inactive form of vitamin D3 which undergoes various levels of hydroxylation to form active vitamin D3 analogs. 1α-Hydroxyvitamin D3 (alfacalcidol) is a synthetic analog that is metabolized to 1,25-dihydroxycholecalciferol, the biologically active form of vitamin D3. Other analogues of cholecalciferol result from different hydroxylations. 24R,25-Dihydroxyvitamin D3 is a catabolite of 25-Dihydroxyvitamin D3 and a putative regulator of developmental bone formation. 24R,25-Dihydroxyvitamin D3 is a substrate for renal 25-hydroxyvitamin D3 1 α-hydroxylase. 24R,25-Dihydroxyvitamin D3 is an endogenous regulator of apo A-I synthesis through a VDR-independent signaling mechanism and an inhibitor of Pi-induced apoptosis through Ca²⁺, PLD, and PLC signaling and through LPA-LPA1/3-G(αi)-PI(3)K-mdm2-mediated p53 degradation.
General description:	(24R)-24,25-Dihydroxyvitamin D₃ or secalciferol is produced in kidney. It is the one of the most active form of vitamin D and an essential circulating vitamin D₃ metabolite.
Packaging:	1 mg in poly bottle
Packaging:	100 μg in poly bottle
Packaging:	Bottomless glass bottle. Contents are inside inserted fused cone.

Symbol	GHS06,GHS08
Signal word	Danger
Hazard statements	H301 + H311 - H330 - H372
Precautionary statements	P280 - P301 + P310 + P330 - P302 + P352 + P312 - P304 + P340 + P310 - P314
Hazard Codes	T+
Risk Statements	28
Safety Statements	28-36/37-45
RIDADR	UN 2811 6.1 / PGII
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (vitamin + pre-vitamin, HPLC)
Storage Temp.	−20°C
UNSPSC	12352205

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