1α-Hydroxyvitamin D₃

SIGMA/17946 - ≥97.0% (HPLC)

Synonym: 1α-Hydroxycholecalciferol; Alfacalcidol

CAS Number: 41294-56-8
Empirical Formula (Hill Notation): C₂₇H₄₄O₂
Molecular Weight: 400.64
EC Number: 255-297-1
MDL Number: MFCD00868328
Linear Formula: C₂₇H₄₄O₂
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-17946-1MG	1 mg	$532.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥97.0% (HPLC)
biological source	synthetic
color	white to off-white
form	powder or crystals
InChI	1S/C27H44O2/c1-18(2)8-6-9-19(3)24-13-14-25-21(10-7-15-27(24,25)5)11-12-22-16-23(28)17-26(29)20(22)4/h11-12,18-19,23-26,28-29H,4,6-10,13-17H2,1-3,5H3/b21-11+,22-12-/t19-,23-,24-,25+,26+,27-/m1/s1
InChI key	OFHCOWSQAMBJIW-AVJTYSNKSA-N
Quality Level	100
SMILES string	CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2C(CCC[C@]12C)=CC=C3C[C@@H](O)C[C@H](O)C3=C
storage temp.	−20°C

Biochem/physiol Actions:	1α-Hydroxyvitamin D₃ facilitates calcium absorption and deposition. It also has an ability to inhibit bone resorption and stimulate bone formation. Alfacalcidol is used for treating various bone diseases such as rickets/osteomalacia, renal osteodystrophy and osteoporosis. It acts as a chemopreventive agent and reduces the risk colitis and carcinogenesis.
Biochem/physiol Actions:	Synthetic vitamin D₃ analog that is metabolized to 1,25-dihydroxycholecalciferol. Inhibits bone resorption and stimulates bone formation. Supresses parathyroid hormone secretion by bovine parathyroid cells.
General description:	1α-Hydroxyvitamin D₃, also known as alfacalcidol, is a synthetic vitamin D₃ analogue, hydroxylated in position one. It is metabolized to 1,25-dihydroxycholecalciferol by 25-hydroxylases.
Packaging:	Bottomless glass bottle. Contents are inside inserted fused cone.

Symbol	GHS06
Signal word	Danger
Hazard statements	H300
Precautionary statements	P301 + P330 + P331 + P310
Hazard Codes	T+
Risk Statements	26/27/28
Safety Statements	28-36/37-45
RIDADR	UN 2811 6.1 / PGI
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥97.0% (HPLC)
Storage Temp.	−20°C
UNSPSC	12352200

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