DL-Buthionine-sulfoximine

SIGMA/19176 - ≥99.0% (TLC)

Synonym: DL-Buthionine (S,R)-sulfoximine; BSO; Buthionine sulfoximine; Butionine sulfoximine

CAS Number: 5072-26-4
Empirical Formula (Hill Notation): C₈H₁₈N₂O₃S
Molecular Weight: 222.31
MDL Number: MFCD00070309
Linear Formula: C₈H₁₈N₂O₃S
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-19176-250MG	250 mg	$104.00 1/EAAdd To Favorites	Add To Favorites
45-19176-1G	1 g	$340.00 1/EAAdd To Favorites	Add To Favorites
45-19176-5G	5 g	$1180.00 1/EAAdd To Favorites	Add To Favorites

assay	≥99.0% (TLC)
biological source	synthetic
form	powder or crystals
InChI	1S/C8H18N2O3S/c1-2-3-5-14(10,13)6-4-7(9)8(11)12/h7,10H,2-6,9H2,1H3,(H,11,12)
InChI key	KJQFBVYMGADDTQ-UHFFFAOYSA-N
mp	215 °C
Quality Level	100
SMILES string	CCCCS(=N)(=O)CCC(N)C(O)=O
solubility	H₂O: 50 mg/mL, clear to almost clear, colorless
storage temp.	2-8°C

Application:	DL-Buthionine-sulfoximine is suitable for use to: • examine whether the inhibition of glutathione by BSO enhances the apoptotic effect of estrogen on antihormone-resistant human breast cancer cells • investigate the effect of BSO on development of bovine embryos • inhibit GSH in several studies • investigate the effect of GSH synthesis on oocyte maturation It may be used to inhibit GSH and evaluate the hepatotoxicity and nephrotoxicity of natural food colorants in the absence of GSH
Biochem/physiol Actions:	DL-Buthionine-sulfoximine inhibits the biosynthesis of Glutathione (GSH) in liver and other peripheral organs. It does not have any effect on GSH in the CNS. It augments the antiproliferative action of reactive oxygen species (e.g., hydrogen peroxide), and agents that indirectly cause accumulation of reactive oxygen species (e.g., 2-methoxyestradiol, which increases intracellular superoxide anion).
Other Notes:	Depletes glutathionine in isolated cells

Symbol	GHS07
Signal word	Warning
Hazard statements	H315 - H319 - H335
Precautionary statements	P302 + P352 - P305 + P351 + P338
Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥99.0% (TLC)
mp	215 °C
Storage Temp.	2-8°C
UNSPSC	12352202