Calcitonin (SP17) Rabbit Monoclonal Antibody
SIGMA/229R-1
Product Type: Chemical
Immunohistochemistry Calcitonin (SP17) on thyroid tissue
| antibody form | culture supernatant |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | SP17, monoclonal |
| conjugate | unconjugated |
| control | medullary carcinoma of thyroid |
| description | For In Vitro Diagnostic Use in Select Regions (See Chart) |
| form | buffered aqueous solution |
| isotype | IgG |
| manufacturer/tradename | Cell Marque™ |
| packaging | bottle of 1.0 mL predilute (229R-17) |
| bottle of 7.0 mL predilute (229R-18) | |
| vial of 0.1 mL concentrate (229R-14) | |
| vial of 0.5 mL concentrate (229R-15) | |
| vial of 1.0 mL concentrate (229R-16) | |
| Quality Level | 100  |
| 500 |
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| shipped in | wet ice |
| species reactivity | human |
| storage temp. | 2-8°C |
| technique(s) | immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500 |
| visualization | cytoplasmic |
| General description: | Calcitonin (thyrocalcitonin) is a 32 amino acid linear polypeptide hormone that is involved in regulating calcium metabolism. It is primarily produced by the parafollicular cells (also known as C cells) of the thyroid gland, though some neuroendocrine cells in other tissues, such as the respiratory and digestive tracts, can also synthesize calcitonin. Anti-calcitonin immunohistochemistry is an effective way for demonstrating the parafollicular C cells in the thyroid3,4 and the tumors arising from them, including C cell hyperplasia of the thyroid and medullary thyroid carcinoma, a neuroendocrine tumor that originates from C cells. Immunohistochemical staining with anti-calcitonin antibody has proven to be an effective way of demonstrating calcitonin-producing cells in the thyroid. C-cell hyperplasia and medullary thyroid carcinomas stain positive for calcitonin. Studies of calcitonin have resulted in the identification of a wide spectrum of C-cell proliferative abnormalities. citationcitationcitationc |
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| Legal Information: | Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany | ||||
| Linkage: | Calcitonin Positive Control Slides, Product No. 229S , are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections). |
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| Other Notes: | For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com | ||||
| Physical form: | Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide | ||||
| Preparation Note: | Download the IFU specific to your product lot and format  Note: This requires a keycode which can be found on your packaging or product label. |
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| Quality: |
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| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 2 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352200 |