Cyclin D1 (EP12) Rabbit Monoclonal Primary Antibody
SIGMA/241R-4
Product Type: Chemical
Immunohistochemistry Cyclin D1 (EP12) on mantle cell lymphoma
| antibody form | culture supernatant |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | EP12, monoclonal |
| conjugate | unconjugated |
| control | mantle cell lymphoma |
| description | For In Vitro Diagnostic Use in Select Regions (See Chart) |
| dilution | 1:100-1:500 |
| form | buffered aqueous solution |
| isotype | IgG |
| manufacturer/tradename | Cell Marque™ |
| packaging | bottle of 1.0 mL predilute (241R-47) |
| bottle of 7.0 mL predilute (241R-48) | |
| vial of 0.1 mL concentrate (241R-44) | |
| vial of 0.5 mL concentrate (241R-45) | |
| vial of 1 mL concentrate (241R-46) | |
| Quality Level | 100  |
| 500 |
|
| shipped in | wet ice |
| species reactivity | human |
| storage temp. | 2-8°C |
| technique(s) | immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable |
| visualization | nuclear |
| General description: | Cyclin D1, one of the key cell cycle regulators, is a putative proto-oncogene overexpressed in a wide variety of human neoplasms. Cyclins are proteins that govern transitions through distinct phases of the cell cycle by regulating the activity of the cyclin-dependent kinases. In mid-to-late G1 phase of the cell cycle, cyclin D1 shows a maximum expression following growth factor stimulation. Anti-cyclin D1 has been successfully employed and is a promising tool for further studies in both cell cycle biology and cancer associated abnormalities. This antibody is useful for separating mantle cell lymphomas (cyclin D1 positive) from chronic lymphocytic leukemia/small lymphocytic lymphoma and follicular lymphomas (cyclin D1 negative). Hairy cell leukemia and plasma cell myeloma can weakly express Cyclin D1. | ||||
| Legal Information: | Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany | ||||
| Linkage: | Cyclin D1 Positive Control Slides, Product No. 241S , are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections). |
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| Other Notes: | For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com | ||||
| Physical form: | Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide | ||||
| Preparation Note: | Download the IFU specific to your product lot and format  Note: This requires a keycode which can be found on your packaging or product label. |
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| Quality: |
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| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 2 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352200 |