α-Tocopherol

SIGMA/258024 - ≥95.5%

Synonym: (±)-α-Tocopherol; DL-all-rac-α-Tocopherol; Vitamin E

CAS Number: 10191-41-0
Empirical Formula (Hill Notation): C₂₉H₅₀O₂
Molecular Weight: 430.71
EC Number: 233-466-0
MDL Number: MFCD00006848
Linear Formula: C₂₉H₅₀O₂
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-258024-5G	5 g	$62.00 1/EAAdd To Favorites		Add To Favorites
45-258024-100G	100 g	$115.00 1/EAAdd To Favorites		Add To Favorites
45-258024-500G	500 g	$400.00 1/EAAdd To Favorites		Add To Favorites

application(s)	cell analysis
assay	≥95.5%
biological source	synthetic
color	yellow to very dark yellow
	faint brown to brown
density	0.950 g/mL at 20 °C (lit.)
form	liquid
InChI	1S/C29H50O2/c1-20(2)12-9-13-21(3)14-10-15-22(4)16-11-18-29(8)19-17-26-25(7)27(30)23(5)24(6)28(26)31-29/h20-22,30H,9-19H2,1-8H3
InChI key	GVJHHUAWPYXKBD-UHFFFAOYSA-N
Quality Level	200
SMILES string	CC(C)CCCC(C)CCCC(C)CCCC1(C)CCc2c(C)c(O)c(C)c(C)c2O1
storage temp.	2-8°C
technique(s)	HPLC: suitable

Application:	α-Tocopherol has been used: • as a standard to determine its concentration by reverse-phase high-performance liquid chromatography • to study its rescue effects on chlorine dioxide (ClO₂) cytotoxicity • to assess its protective effects on acetaminophen (APAP)-mediated liver damage
Biochem/physiol Actions:	Tocopherols (TCP) (vitamin E) are a series (α, β, γ and δ) of chiral organic molecules that vary in their degree of methylation of the phenol moiety of the chromanol ring. Tocopherols are lipid soluble anti-oxidants that protect cell membranes from oxidative damage. α-Tocopherol is the form of tocopherol preferentially absorbed by homo sapiens. Various isofroms and analogues of tocopherol have opposing and differentiated regulatory activities in vivo.
General description:	α-Tocopherol is the active form of vitamin E. It functions as an hydroperoxyl radical scavenger and protects the organism from oxidative damage. α-Tocopherol plays a crucial role in cell signalling and regulating immune responses. α-Tocopherol deficiency is associated with abetalipoproteinemia, cystic fibrosis and celiac disease. It has antiproliferative effects. It inhibits arsenite-induced damage of human fibroblasts.
Packaging:	5, 100, 500 g in glass bottle