Cloxacillin sodium salt

SIGMA/27555 - ≥95.0% (HPLC)

Synonym: 3-(o-Chlorophenyl)-5-methyl-4-isoxazolylpenicillin sodium salt; Syntarpen sodium salt

CAS Number: 642-78-4
Empirical Formula (Hill Notation): C₁₉H₁₇ClN₃NaO₅S
Molecular Weight: 457.86
EC Number: 211-390-9
MDL Number: MFCD00063568
Linear Formula: C₁₉H₁₇ClN₃NaO₅S
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-27555-1G-F	1 g	$71.90 1/EAAdd To Favorites	Add To Favorites
45-27555-5G-F	5 g	$289.00 1/EAAdd To Favorites	Add To Favorites

antibiotic activity spectrum	Gram-positive bacteria
assay	≥95.0% (HPLC)
biological source	semisynthetic
color	white to off-white
form	powder or crystals
impurities	≤5% Total impurities (anhydrous)
InChI	1S/C19H18ClN3O5S.Na/c1-8-11(12(22-28-8)9-6-4-5-7-10(9)20)15(24)21-13-16(25)23-14(18(26)27)19(2,3)29-17(13)23;/h4-7,13-14,17H,1-3H3,(H,21,24)(H,26,27);/q;+1/p-1/t13-,14+,17-;/m1./s1
InChI key	SCLZRKVZRBKZCR-SLINCCQESA-M
mode of action	cell wall synthesis \| interferes
Quality Level	200
SMILES string	[Na+].Cc1onc(-c2ccccc2Cl)c1C(=O)N[C@H]3[C@H]4SC(C)(C)[C@@H](N4C3=O)C([O-])=O
storage temp.	2-8°C

Application:	Cloxacillin is a semisynthetic antibiotic in the same class as penicillin. Cloxacillin is used against staphylococci that produce β-lactamase. It is used to study the role of pH in antibiotic effectiveness and how oxgall, acid, and hydrogen peroxide stress effects the susceptibility of Bifidobacteria.
Biochem/physiol Actions:	Cloxacillin interferes with the last stage of bacterial cell wall synthesis by binding to penicillin-binding proteins. This inhibits the necessary cross-linking and leads to autolysis of the bacteria by autolysins.
General description:	Chemical structure: ß-lactam
Other Notes:	Keep container tightly closed in a dry and well-ventilated place.

RIDADR	NONH for all modes of transport
WGK Germany	WGK 2
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥95.0% (HPLC)
Storage Temp.	2-8°C
UNSPSC	51102829