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Colistin sodium methanesulfonate

SIGMA/27655 - from Bacillus colistinus

Synonym: Colimycin sodium methanesulfonate; Methanesulfonic acid derivative of Polymyxin E; Polymyxin E sodium methanesulfonate

CAS Number: 8068-28-8
Empirical Formula (Hill Notation): C58H115N16Na5O28S5
Molecular Weight: 1759.90
EC Number: 232-516-9
MDL Number: MFCD00130824
Linear Formula: C58H115N16Na5O28S5
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-27655-1G 1 g
 $177.00
1/EA		 Add To Favorites
45-27655-5G 5 g
 $747.00
1/EA		 Add To Favorites

 

antibiotic activity spectrum Gram-negative bacteria
biological source Bacillus colistinus
color white to off-white
form powder or crystals
ign. residue ~20%
InChI 1S/C53H100N16O13.5CH4O3S.5Na/c1-9-30(6)12-10-11-13-41(72)60-33(14-20-54)48(77)69-43(32(8)71)53(82)65-36(17-23-57)45(74)64-38-19-25-59-52(81)42(31(7)70)68-49(78)37(18-24-58)62-44(73)34(15-21-55)63-50(79)39(26-28(2)3)67-51(80)40(27-29(4)5)66-46(75)35(16-22-56)61-47(38)76;5*1-5(2,3)4;;;;;/h28-40,42-43,70-71H,9-27,54-58H2,1-8H3,(H,59,81)(H,60,72)(H,61,76)(H,62,73)(H,63,79)(H,64,74)(H,65,82)(H,66,75)(H,67,80)(H,68,78)(H,69,77);5*1H3,(H,2,3,4);;;;;/q;;;;;;5*+1/p-5/t30?,31-,32-,33+,34-,35+,36+,37+,38+,39+,40-,42+,43+;;;;;;;;;;/m1........../s1
InChI key WSDSONZFNWDYGZ-BKFDUBCBSA-I
loss ≤5.0% loss on drying
mode of action cell membrane | interferes
pH 6.5-8.5
Quality Level 200 
SMILES string [Na+].[Na+].[Na+].[Na+].[Na+].CS([O-])(=O)=O.CS([O-])(=O)=O.CS([O-])(=O)=O.CS([O-])(=O)=O.CS([O-])(=O)=O.CCC(C)CCCCC(=O)N[C@@H](CCN)C(=O)N[C@@H](C(C)O)C(=O)N[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@@H](NC(=O)[C@H](CCN)NC(=O)[C@@H](CCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCN)NC1=O)C(C)O
storage temp. 2-8°C
Application: Colistin sodium methanesulfate is used to permeabilize bacterial cell membranes and to study mannose-resistant haemagglutination.
Biochem/physiol Actions: Colistin sodium methanesulfate is a cyclopolypeptide antibiotic with endotoxin-binding capacity Colistin′s activity stems from the hydrophobic and hydrophillic regions. They solubilze the cytoplasmic membrane which contributes to the bactericidal effect .
Biochem/physiol Actions: Mode of Action: Binds to lipids on the cell cytoplasmic membrane of Gram-negative bacteria and disrupts the cell wall integrity.
Antimicrobial spectrum: Gram-negative bacteria.
General description: Chemical structure: peptide
Other Notes: Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place. Keep in a dry place.
Packaging: 1g, 5g
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Storage Temp. 2-8°C
UNSPSC 51101500

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