Ksp-cadherin (MRQ-33) Mouse Monoclonal Antibody

SIGMA/276M-9

Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-276M-94	0.1 mL	$0.00 1/EA CALL FOR PRICEAdd To Favorites	Add To Favorites
45-276M-95	0.5 mL	$0.00 1/EA CALL FOR PRICEAdd To Favorites	Add To Favorites
45-276M-96	1 mL	$0.00 1/EA CALL FOR PRICEAdd To Favorites	Add To Favorites
45-276M-97	1 mL	$0.00 1/EA CALL FOR PRICEAdd To Favorites	Add To Favorites
45-276M-98	7 mL	$0.00 1/EA CALL FOR PRICEAdd To Favorites	Add To Favorites

Immunohistochemistry Ksp-cadherin (MRQ-33) on kidney

antibody form	culture supernatant
antibody product type	primary antibodies
biological source	mouse
clone	MRQ-33, monoclonal
conjugate	unconjugated
control	kidney
description	For In Vitro Diagnostic Use in Select Regions (See Chart)
form	buffered aqueous solution
isotype	IgG1
manufacturer/tradename	Cell Marque^™
packaging	bottle of 1.0 mL predilute (276M-97)
	bottle of 7.0 mL predilute (276M-98)
	vial of 0.1 mL concentrate (276M-94)
	vial of 0.5 mL concentrate (276M-95)
	vial of 1.0 mL concentrate (276M-96)
Quality Level	100
	500
shipped in	wet ice
species reactivity	human
storage temp.	2-8°C
technique(s)	immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500
visualization	membranous

General description:

Kidney-specific cadherin (Ksp-cadherin) is a novel, kidney-specific member of the cadherin family of cell adhesion molecules. Within the kidney, Ksp-cadherin is found exclusively in the basolateral membrane of renal tubular epithelial cells and collecting duct cells, and not in glomeruli, renal interstitial cells, or blood vessels. Different cadherins, including E-cadherin, cadherin-6, and N-cadherin, have been investigated in renal cell cancers, demonstrating possible correlations of tumor dedifferentiation and the presence of lymph node metastasis with loss of cadherins. Mazal et al. investigated the utility of using Ksp-cadherin to distinguish chromophobe renal cell carcinoma from oncocytoma. He found a membranous pattern of staining in 96% of 30 chromophobe carcinomas, and in only 6% of 31 oncocytomas leading them to conclude that this is a useful antibody in differentiating these two lesions. Shen et al., on the other hand, found Ksp-cadherin positivity in 100% of 13 chromophobe RCCs, and 95% of 20 oncocytomas.

Associated products: CK7, RCC

Legal Information:

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

Linkage:

Ksp-cadherin Positive Control Slides, Product No. 276S External link

, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Other Notes:

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Physical form:

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Preparation Note:

Download the IFU specific to your product lot and format External link

Note: This requires a keycode which can be found on your packaging or product label.

Quality:

IVD

RUO

RIDADR	NONH for all modes of transport
WGK Germany	WGK 2
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Storage Temp.	2-8°C
UNSPSC	12352203