Synonym: 11β,21-Dihydroxy-4-pregnene-3,20-dione; 11β,21-Dihydroxyprogesterone; 4-Pregnene-11β,21-diol-3,20-dione; Kendall’s Compound B; Reichstein’s Substance H
CAS Number: 50-22-6
Empirical Formula (Hill Notation): C21H30O4
Molecular Weight: 346.46
EC Number: 200-019-6
MDL Number: MFCD00037715
Linear Formula: C21H30O4
Product Type: Chemical
| assay |
≥98.5% (HPLC) |
| biological source |
synthetic |
| form |
powder or crystals |
| functional group |
ketone |
| InChI |
1S/C21H30O4/c1-20-8-7-13(23)9-12(20)3-4-14-15-5-6-16(18(25)11-22)21(15,2)10-17(24)19(14)20/h9,14-17,19,22,24H,3-8,10-11H2,1-2H3/t14-,15-,16+,17-,19+,20-,21-/m0/s1 |
| InChI key |
OMFXVFTZEKFJBZ-HJTSIMOOSA-N |
| mp |
179-183 °C |
| |
179-183 °C (lit.) |
| optical activity |
[α]20/D +223±3°, c = 1% in ethanol |
| Quality Level |
200  |
| SMILES string |
C[C@]12C[C@H](O)[C@H]3[C@@H](CCC4=CC(=O)CC[C@]34C)[C@@H]1CC[C@@H]2C(=O)CO |
| Application: |
Corticosterone was used to study the adrenoceptor signaling in rats, lizards or in vitro. It was also used in immune suppression experiment. |
| Biochem/physiol Actions: |
Corticosterone is synthesized from cholesterol in the adrenal cortex that activates both mineralocorticoid and glucocorticoid receptors. The role of corticosterones is vital for reproductive processes including ovulation, lutenization, development of oocytes, parturition and lactation. The metabolism of corticosterone is modulated by the enzyme 11β-hydroxysteroid dehydrogenase. |
| General description: |
Corticosterone (Cort) is a glucocorticoid hormone. It is also the principal hormone that mediates stress responses in birds. It is the primary adrenal cortical steroid in rat plasma. The influence of maternal Cort exposure on the developing placenta has been studied in a mouse model. |
| Packaging: |
Bottomless glass bottle. Contents are inside inserted fused cone. |
| Preparation Note: |
Corticosterone is soluble in chloroform and ethanol. |
| Hazard Codes |
Xi |
| Risk Statements |
43 |
| Safety Statements |
36 |
| RIDADR |
NONH for all modes of transport |
| WGK Germany |
WGK 3 |
| Purity |
≥98.5% (HPLC) |
| mp |
179-183 °C (lit.); 179-183 °C |
| UNSPSC |
12352211 |
