BOB.1 (SP92) Rabbit Monoclonal Antibody

SIGMA/294R-1

Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-294R-14	0.1 mL	$0.00 1/EA CALL FOR PRICEAdd To Favorites	Add To Favorites
45-294R-15	0.5 mL	$0.00 1/EA CALL FOR PRICEAdd To Favorites	Add To Favorites
45-294R-16	1 mL	$0.00 1/EA CALL FOR PRICEAdd To Favorites	Add To Favorites
45-294R-17	1 mL	$0.00 1/EA CALL FOR PRICEAdd To Favorites	Add To Favorites
45-294R-18	7 mL	$0.00 1/EA CALL FOR PRICEAdd To Favorites	Add To Favorites

Immunohistochemistry BOB.1 (SP92) on tonsil

antibody form	culture supernatant
antibody product type	primary antibodies
biological source	rabbit
clone	SP92, monoclonal
conjugate	unconjugated
control	B-cell lymphoma, tonsil
description	For In Vitro Diagnostic Use in Select Regions (See Chart)
form	buffered aqueous solution
isotype	IgG1
manufacturer/tradename	Cell Marque^™
packaging	bottle of 1.0 mL predilute (294R-17)
	bottle of 7.0 mL predilute (294R-18)
	vial of 0.1 mL concentrate (294R-14)
	vial of 0.5 mL concentrate (294R-15)
	vial of 1.0 mL concentrate (294R-16)
Quality Level	100
	500
shipped in	wet ice
species reactivity	human
storage temp.	2-8°C
technique(s)	immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500
visualization	nuclear

General description:	Expression of BOB.1/OBF.1 is restricted largely to mature B-cells. Germinal center B-cells normally demonstrate strong staining for BOB.1, as do mantle-zone B-cells, and plasma cells. Analyses of BOB.1/OBF.1 expression in a variety of established B-cell lines representing different stages of B-cell development has suggested a constitutive, B-cell-specific expression pattern. Because they are germinal center derived, L&H cells in nodular lymphocyte predominant Hodgkin lymphoma are consistenty immunoreactive for BOB.1. Conversely, the Hodgkin/Reed- Sternberg cells in classical Hodgkin lymphoma either do not express both (80%) or express only one (20%) of the two proteins. In B-cell lymphomas, the highest expression levels for BOB.1/OBF.1 are reported in follicular center lymphomas, diffuse large B-cell lymphomas and Burkitt lymphomas.B-CLL, MALT-type, and mantle cell lymphomas score negative or display an heterogenous/weaker reactivity.10-11 Studies have suggested that anti-BOB. has a high predictive value in discriminating primary mediastinal B-cell lymphoma from classical Hodgkin disease.Approximately 50% of acute myeloid leukemias express BOB.1.
Legal Information:	Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany
Linkage:	BOB.1 Positive Control Slides, Product No. 294S , are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).
Other Notes:	For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com
Physical form:	Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide
Preparation Note:	Download the IFU specific to your product lot and format Note: This requires a keycode which can be found on your packaging or product label.

RIDADR	NONH for all modes of transport
WGK Germany	WGK 2
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Storage Temp.	2-8°C
UNSPSC	12352203