Cyclosporin A

SIGMA/30024 - 97.0-101.5% (on dried basis)

Synonym: Antibiotic S 7481F1; Cyclosporine

CAS Number: 59865-13-3
Empirical Formula (Hill Notation): C₆₂H₁₁₁N₁₁O₁₂
Molecular Weight: 1202.61
MDL Number: MFCD00274558
Linear Formula: C₆₂H₁₁₁N₁₁O₁₂
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-30024-25MG	25 mg	$156.00 1/EA		Add To Favorites
45-30024-100MG	100 mg	$442.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

antibiotic activity spectrum	fungi
assay	97.0-101.5% (on dried basis)
color	white to off-white
form	powder
InChI	1S/C62H111N11O12/c1-25-27-28-40(15)52(75)51-56(79)65-43(26-2)58(81)67(18)33-48(74)68(19)44(29-34(3)4)55(78)66-49(38(11)12)61(84)69(20)45(30-35(5)6)54(77)63-41(16)53(76)64-42(17)57(80)70(21)46(31-36(7)8)59(82)71(22)47(32-37(9)10)60(83)72(23)50(39(13)14)62(85)73(51)24/h25,27,34-47,49-52,75H,26,28-33H2,1-24H3,(H,63,77)(H,64,76)(H,65,79)(H,66,78)/b27-25+/t40-,41+,42-,43+,44+,45+,46+,47+,49+,50+,51+,52-/m1/s1
InChI key	PMATZTZNYRCHOR-CGLBZJNRSA-N
mode of action	enzyme \| inhibits
Quality Level	200
SMILES string	CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)CC=CC)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O)C(C)C
storage temp.	2-8°C

Application:	Cyclosporin A is used for immunosuppressive studies .
Biochem/physiol Actions:	A fungal metabolite possessing potent immunosuppressive properties. It inhibits the T-cell receptor signal transduction pathway via the formation of cyclosporin A−cyclophilin complex that inhibits calcineurin (protein phosphatase 2B). Inhibits nitric oxide synthesis induced by interleukin 1α, lipopolysaccharides and TNFα. Can block cytochrome c release from mitochondria.
Biochem/physiol Actions:	Potent immunosuppressant; inhibits nitric oxide synthesis induced by interleukin 1α, lipopolysaccharides and TNFα; blocks cytochrome c release from mitochondria.
General description:	Chemical structure: peptide
Other Notes:	Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.Storage class (TRGS 510): Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects.
Packaging:	25, 100 mg in glass bottle
Packaging:	Bottomless glass bottle. Contents are inside inserted fused cone.

Symbol	GHS07,GHS08
Signal word	Danger
Hazard statements	H302 - H350 - H360FD
Precautionary statements	P201 - P202 - P264 - P270 - P301 + P312 - P308 + P313
Hazard Codes	T
Risk Statements	45-60-22
Safety Statements	53-45
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3

Purity	97.0-101.5% (on dried basis)
Storage Temp.	2-8°C
UNSPSC	51102829

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