Cyclosporin A
SIGMA/30024 - 97.0-101.5% (on dried basis)
Synonym: Antibiotic S 7481F1; Cyclosporine
CAS Number: 59865-13-3
Empirical Formula (Hill Notation): C62H111N11O12
Molecular Weight: 1202.61
MDL Number: MFCD00274558
Linear Formula: C62H111N11O12
Product Type: Chemical
antibiotic activity spectrum | fungi |
assay | 97.0-101.5% (on dried basis) |
color | white to off-white |
form | powder |
InChI | 1S/C62H111N11O12/c1-25-27 |
InChI key | PMATZTZNYRCHOR-CGLBZJNRSA |
mode of action | enzyme | inhibits |
Quality Level | 200 |
SMILES string | CC[C@@H]1NC(=O)[C@H]([C@H |
storage temp. | 2-8°C |
Application: | Cyclosporin A is used for immunosuppressive studies . |
Biochem/physiol Actions: | A fungal metabolite possessing potent immunosuppressive properties. It inhibits the T-cell receptor signal transduction pathway via the formation of cyclosporin A−cyclophilin complex that inhibits calcineurin (protein phosphatase 2B). Inhibits nitric oxide synthesis induced by interleukin 1α, lipopolysaccharides and TNFα. Can block cytochrome c release from mitochondria. |
General description: | Chemical structure: peptide |
Other Notes: | Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.Storage class (TRGS 510): Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects. |
Packaging: | 25, 100 mg in glass bottle |
Packaging: | Bottomless glass bottle. Contents are inside inserted fused cone. |
Symbol | GHS07,GHS08 |
Signal word | Danger |
Hazard statements | H302 - H350 - H360FD |
Precautionary statements | P201 - P202 - P264 - P270 - P301 + P312 - P308 + P313 |
Hazard Codes | T |
Risk Statements | 45-60-22 |
Safety Statements | 53-45 |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Purity | 97.0-101.5% (on dried basis) |
Storage Temp. | 2-8°C |
UNSPSC | 51101500 |