Dansylcadaverine

SIGMA/30432 - suitable for fluorescence, BioReagent, ≥99.0% (HPLC)

Synonym: N-(5-Aminopentyl)-5-dimethylaminonaphthalene-1-sulfonamide; N-(Dimethylaminonaphthalenesulfonyl)-1,5-pentanediamine; Monodansyl cadaverine

CAS Number: 10121-91-2
Empirical Formula (Hill Notation): C₁₇H₂₅N₃O₂S
Molecular Weight: 335.46
EC Number: 233-326-9
MDL Number: MFCD00042704
Linear Formula: C₁₇H₂₅N₃O₂S
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-30432-100MG	100 mg	$52.00 1/EAAdd To Favorites	Add To Favorites
45-30432-1G	1 g	$261.00 1/EAAdd To Favorites	Add To Favorites

assay	≥99.0% (HPLC)
fluorescence	λ_ex 335 nm; λ_em 518 nm in methanol
	λ_ex 338 nm; λ_em 500 nm (Reaction product)
InChI	1S/C17H25N3O2S/c1-20(2)16-10-6-9-15-14(16)8-7-11-17(15)23(21,22)19-13-5-3-4-12-18/h6-11,19H,3-5,12-13,18H2,1-2H3
InChI key	MLEBFEHOJICQQS-UHFFFAOYSA-N
mp	137-140 °C
product line	BioReagent
Quality Level	100
SMILES string	CN(C)c1cccc2c(cccc12)S(=O)(=O)NCCCCCN
storage temp.	−20°C
suitability	suitable for fluorescence

Application:	Dansylcadaverine (MDC), an autofluorescent dye, is used to monitor autophagy. MDC accumulates in autophagic vacuoles due to a combination of ion trapping and specific interactions with membrane lipids.
Biochem/physiol Actions:	Inhibitor of the fibrin-stabilizing fator; Inhibitor of epidermal growth factor (EGF) internalization; Fluorescent substrate for the assay of transamidating enzymes.
Biochem/physiol Actions:	The autofluorescent dye dansylcadaverine, or monodansylcadaverine (MDC), is commonly used to monitor autophagy. MDC preferentially accumulates in autophagic vacuoles due to a combination of ion trapping and specific interactions with membrane lipids.
Other Notes:	Solubility of dansylcadaverine is tested in methanol (10 mg/mL). It has also been reported that dansylcadaverine is soluble in DMSO and acetic acid.
Packaging:	air sensitive, handled under inert gas
Packaging:	Bottomless glass bottle. Contents are inside inserted fused cone.

Symbol	GHS07
Signal word	Warning
Hazard statements	H315 - H319 - H335
Precautionary statements	P302 + P352 - P305 + P351 + P338
Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥99.0% (HPLC)
mp	137-140 °C
Storage Temp.	−20°C
UNSPSC	12352108