Dansylcadaverine
SIGMA/30432 - BioReagent, suitable for fluorescence, ≥99.0% (HPLC)
Synonym: N-
CAS Number: 10121-91-2
Empirical Formula (Hill Notation): C17H25N3O2S
Molecular Weight: 335.46
EC Number: 233-326-9
MDL Number: MFCD00042704
Linear Formula: C17H25N3O2S
Product Type: Chemical
assay | ≥99.0% (HPLC) |
fluorescence | λex 335 nm; λem 518 nm in methanol |
λex 338 nm; λem 500 nm (Reaction product) | |
InChI | 1S/C17H25N3O2S/c1-20(2)16 |
InChI key | MLEBFEHOJICQQS-UHFFFAOYSA |
mp | 137-140 °C |
product line | BioReagent |
Quality Level | 100 |
SMILES string | CN(C)c1cccc2c(cccc12)S(=O |
storage temp. | −20°C |
suitability | suitable for fluorescence |
Application: | Dansylcadaverine (MDC), an autofluorescent dye, is used to monitor autophagy. MDC accumulates in autophagic vacuoles due to a combination of ion trapping and specific interactions with membrane lipids. |
Biochem/physiol Actions: | Inhibitor of the fibrin-stabilizing fator; Inhibitor of epidermal growth factor (EGF) internalization; Fluorescent substrate for the assay of transamidating enzymes. |
Biochem/physiol Actions: | The autofluorescent dye dansylcadaverine, or monodansylcadaverine (MDC), is commonly used to monitor autophagy. MDC preferentially accumulates in autophagic vacuoles due to a combination of ion trapping and specific interactions with membrane lipids. |
Other Notes: | Solubility of dansylcadaverine is tested in methanol (10 mg/mL). It has also been reported that dansylcadaverine is soluble in DMSO and acetic acid. |
Packaging: | air sensitive, handled under inert gas |
Packaging: | Bottomless glass bottle. Contents are inside inserted fused cone. |
Symbol | GHS07 |
Signal word | Warning |
Hazard statements | H315 - H319 - H335 |
Precautionary statements | P302 + P352 - P305 + P351 + P338 |
Hazard Codes | Xi |
Risk Statements | 36/37/38 |
Safety Statements | 26-36 |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥99.0% (HPLC) |
mp | 137-140 °C |
Storage Temp. | −20°C |
UNSPSC | 12352200 |