Daunorubicin hydrochloride

SIGMA/30450 - ≥90% (HPLC)

Synonym: Daunomycin hydrochloride

CAS Number: 23541-50-6
Empirical Formula (Hill Notation): C₂₇H₂₉NO₁₀ · HCl
Molecular Weight: 563.98
EC Number: 245-723-4
MDL Number: MFCD04974507
Linear Formula: C₂₇H₂₉NO₁₀ · HCl
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-30450-5MG	5 mg	$176.00 1/EAAdd To Favorites		Add To Favorites
45-30450-25MG	25 mg	$600.00 1/EAAdd To Favorites		Add To Favorites

antibiotic activity spectrum	neoplastics
assay	≥90% (HPLC)
biological source	synthetic
color	red to deep red
form	powder
InChI	1S/C27H29NO10.ClH/c1-10-22(30)14(28)7-17(37-10)38-16-9-27(35,11(2)29)8-13-19(16)26(34)21-20(24(13)32)23(31)12-5-4-6-15(36-3)18(12)25(21)33;/h4-6,10,14,16-17,22,30,32,34-35H,7-9,28H2,1-3H3;1H/t10-,14-,16-,17-,22+,27-;/m0./s1
InChI key	GUGHGUXZJWAIAS-QQYBVWGSSA-N
mode of action	DNA synthesis \| interferes
Quality Level	200
SMILES string	Cl.COc1cccc2C(=O)c3c(O)c4C[C@](O)(C[C@H](O[C@H]5C[C@H](N)[C@H](O)[C@H](C)O5)c4c(O)c3C(=O)c12)C(C)=O
storage temp.	2-8°C

Application:	Daunorubicin hydrochloride is used in photostability, antileukemic, and drug metabolism studies.
Biochem/physiol Actions:	On binding to DNA, daunomycin intercalates, with its daunosamine residue directed toward the minor groove. Daunomycin effectively binds to every 3 base pairs which causes unwinding.
Biochem/physiol Actions:	Potent anticancer agent. Inhibits DNA and RNA synthesis as sequence specific ds-DNA intercalating agent.
General description:	Chemical structure: aminoglycoside
Other Notes:	Keep container tightly closed in a dry and well-ventilated place. Hygroscopic. Store under inert gas.
Packaging:	5 mg, 25 mg

Symbol	GHS06,GHS08
Signal word	Danger
Hazard statements	H301 - H341 - H351 - H360FD
Precautionary statements	P201 - P202 - P264 - P270 - P280 - P301 + P310
Hazard Codes	Xn
Risk Statements	22-40-42/43
Safety Statements	22-36/37-45
RIDADR	UN 2811 6.1 / PGIII
WGK Germany	WGK 3