Daunorubicin hydrochloride
SIGMA/30450 - ≥90% (HPLC)
Synonym: Daunomycin hydrochloride
CAS Number: 23541-50-6
Empirical Formula (Hill Notation): C27H29NO10 · HCl
Molecular Weight: 563.98
EC Number: 245-723-4
MDL Number: MFCD04974507
Linear Formula: C27H29NO10 · HCl
Product Type: Chemical
antibiotic activity spectrum | neoplastics |
assay | ≥90% (HPLC) |
biological source | synthetic |
color | red to deep red |
form | powder |
InChI | 1S/C27H29NO10.ClH/c1-10-2 |
InChI key | GUGHGUXZJWAIAS-QQYBVWGSSA |
mode of action | DNA synthesis | interferes |
Quality Level | 200 |
SMILES string | Cl.COc1cccc2C(=O)c3c(O)c4 |
storage temp. | 2-8°C |
Application: | Daunorubicin hydrochloride is used in photostability, antileukemic, and drug metabolism studies. |
Biochem/physiol Actions: | On binding to DNA, daunomycin intercalates, with its daunosamine residue directed toward the minor groove. Daunomycin effectively binds to every 3 base pairs which causes unwinding. |
Biochem/physiol Actions: | Potent anticancer agent. Inhibits DNA and RNA synthesis as sequence specific ds-DNA intercalating agent. |
General description: | Chemical structure: aminoglycoside |
Other Notes: | Keep container tightly closed in a dry and well-ventilated place. Hygroscopic. Store under inert gas. |
Packaging: | 5 mg, 25 mg |
Symbol | GHS06,GHS08 |
Signal word | Danger |
Hazard statements | H301 - H341 - H351 - H360FD |
Precautionary statements | P201 - P202 - P264 - P270 - P280 - P301 + P310 |
Hazard Codes | Xn |
Risk Statements | 22-40-42/43 |
Safety Statements | 22-36/37-45 |
RIDADR | UN 2811 6.1 / PGIII |
WGK Germany | WGK 3 |
Purity | ≥90% (HPLC) |
Storage Temp. | 2-8°C |
UNSPSC | 51101500 |